Diagnostic Role of Presepsin in Patients with Liver Cirrhosis and Bacterial Infection | ||
| Zagazig University Medical Journal | ||
| Article 24, Volume 30, Issue 4, July 2024, Pages 1244-1256 PDF (609.59 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2023.241525.2944 | ||
| Authors | ||
| Ahmed Abdelhakim Abdelmaksoud* 1; Talaat Fathy2; Heba F. Pasha3; Maysaa A. Saeed4 | ||
| 1M.B; B.Ch.; Faculty of Medicine, Zagazig University | ||
| 2Zagazyg Uneversity, Faculty of Medicine | ||
| 3Professor of Medical Biochemistry, Faculty of Medicine, Zagazig University | ||
| 4Professor of Tropical Medicine, Faculty of Medicine, Zagazig University | ||
| Abstract | ||
| Background: Presepsin is secreted in response to bacterial phagocytosis, and it has been found that people with liver cirrhosis are at a higher risk of developing bacterial infections. We aimed to evaluate the diagnostic role of presepsin in Patients with liver cirrhosis and bacterial infection. Methods: Our case-control study included 96 cases with liver cirrhosis, divided into 2 groups according to the results of culture and sensitivity. Group I involved 48 patients with liver cirrhosis (child B or C) with a bacterial infection. Group II: involved 48 cases with liver cirrhosis (child B or C) without bacterial infection. Estimation of serum presepsin level was done for all participants. Results: The C reactive protein (CRP), serum procalcitonin, and presepsin (Log PSP) were significantly higher among cirrhotic patients cases with bacterial infection with p-value <0.001 for each when compared to cirrhotic patients without bacterial infection, significant positive correlations were found between Log(PSP) and both CRP and serum procalcitonin (p=0.004, 0.003 respectively). At a cut-off value of <3.1 log PSP could diagnose bacterial infection with the area under the curve 0.698, with specificity of 63.3%, sensitivity of 54.2%, positive predictive value (PPV) 66.5%, negative predictive value (NPV) 64.5% and overall accuracy 68.8%. The combination of CRP and Log PSP had the best diagnostic value with sensitivity of 95.8%, specificity 93.7%, PPV 93.9%, and NPV 95.7%. Conclusions: Presepsin can play a role in diagnosing bacterial infection in patients with liver cirrhosis. Presepsin and CRP increased the diagnostic accuracy of bacterial infection in cirrhotic patients. | ||
| Keywords | ||
| Presepsin; Liver Cirrhosis; Bacterial Infection | ||
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