Study of Adding Pheniramine to Midazolam on Sedation during Colonoscopy in Tanta University Hospital: A Comparative Study | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 54, Volume 93, Issue 1, October 2023, Pages 7253-7256 PDF (532.04 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2023.322111 | ||
| Abstract | ||
| Background:The whole big bowel may be seen inspected during a colonoscopy. The gold standard for the early identification of polyps and colorectal cancer, it is safe and reliable. The most often used drugs for moderate sedation are midazolam and fentanyl, which are benzodiazepines or mixtures of benzodiazepines and opioids. Objective: The aim of the current study was to assess the safety and viability ofmidazolam with that of midazolam/pheniramine in sedation of patients undergoing colonoscopy. Patients and methods:This clinical trial was carried out on 90 patients indicated for colonoscopy. Patients were randomized into 2 equal groups: Group A was sedated using midazolam (Dormicum) 5mg given slowly intravenously over one minute, and Group B was sedated using phinarimine 25mg (Avil) ampule given slowly intravenously 5 minutes before the procedure, then midazolam 5mg given slowly intravenously over one minute. Results: There was a significant delay in time for initiation of sedation, and procedure time in Group A. But there was a significant delay in the post-procedure time and recovery time in Group B. There was a significant increase in satisfaction scale, endoscopist's satisfaction in patients of Group B. Conclusion: Use of intravenous pheniramine maleate given before initiation of midazolam is superior to using midazolam alone in the decrease of preprocedural’s anxiety, quality improvement for moderate sedation during colonoscopy, high satisfaction score for the patients, high tolerance to the procedure and higher endoscopes’ satisfaction during the procedure. | ||
| Keywords | ||
| Pheniramine; Midazolam; Sedation; Colonoscopy | ||
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