(2023). Prognostic Effect of Nodular and Infiltrating Tumor deposits of colorectal carcinoma and its relation to neoadjuvant therapy; a retrospective study. test, 11(4), 275-289.
. "Prognostic Effect of Nodular and Infiltrating Tumor deposits of colorectal carcinoma and its relation to neoadjuvant therapy; a retrospective study". test, 11, 4, 2023, 275-289.
(2023). 'Prognostic Effect of Nodular and Infiltrating Tumor deposits of colorectal carcinoma and its relation to neoadjuvant therapy; a retrospective study', test, 11(4), pp. 275-289.
Prognostic Effect of Nodular and Infiltrating Tumor deposits of colorectal carcinoma and its relation to neoadjuvant therapy; a retrospective study. test, 2023; 11(4): 275-289.

Prognostic Effect of Nodular and Infiltrating Tumor deposits of colorectal carcinoma and its relation to neoadjuvant therapy; a retrospective study

SECI Oncology Journal
Volume 11, Issue 4, October 2023, Pages 275-289
Abstract
Objective: This study aimed to assess correlation between tumor deposits and 
clinicopathological characteristics of colorectal cancer, evaluate the relationship 
between tumor deposits and prognosis of colorectal cancer (CRC) patient and 
the relationship between tumor deposits and neoadjuvant chemotherapy.
Methods: One hundred and thirty three cases with stage I–IV CRC who 
underwent primary tumor resection for operable cases in the period between 
January 2017 and December 2019 and followed up until June 2022 were 
included in this study. Cases were selected from the registry of the Pathology 
Department at South Egypt Carcinoma Institute (SECI). The H & E stained 
slides were examined initially and the tumors were staged according to AJCC 
TNM classification eighth edition.
Result: Tumor deposit (TD) was detected in 39 (29.3%) of the studied cases, 
while 94 (70.7%) cases were negative for TDs. Statistical significance 
association was detected between the presence of TDs and tumor invasion and 
lymph node (LN) metastasis (P=0.004 and P=0.000). There was statistical 
significance between TDs and prognosis as follow; presence of TDs decreases 
the overall survival and DFS (associated with poor prognosis). Both are 
inversely affected (decreased) (P=0.000, P=0.006) respectively
Conclusion: this study shows that tumor deposit is an independent prognostic 
factor in colorectal carcinoma patients that affects negatively both OS and DFS 
with significant association between it and lymphovascular invasion (LVI), 
perineural invasion (PNI), LN metastasis, tumor invasion. Furthermore, 
presence of both TDs and LN metastases confers additive risk.
Keywords
Colorectal carcinoma; tumor deposit; lymph node; neoadjuvant therapy; prognosis
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