Human Genetic as Risk Factors for COVID-19 Progression | ||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||
| Volume 15, Issue 2, December 2023, Pages 529-561 PDF (634.26 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsc.2023.322926 | ||
| Authors | ||
| Mohamed Hosney1; Radwa Reda Sallam2; Mariam Saber Sayed1 | ||
| 1Zoology Department, Faculty of Science, Cairo University, 12613, Giza, Egypt. | ||
| 2Department of Chemistry, Faculty of Science, Cairo University, 12613, Giza, Egypt. | ||
| Abstract | ||
| Background: Thousands of people have already died as a result of the 2019 coronavirus disease pandemic (COVID-19), which was brought on by the SARS-CoV-2 coronavirus. There were many unimaginable cases of illness in Washington in 2020 as a first case, and then it was transmitted to Wuhan, Germany, France, Italy, Spain, the United Kingdom and China. The newly discovered SARS-CoV, MERS-CoV, and SARS-CoV-2 are believed to be natural and not laboratory synthetic. The COVID-19 pandemic may be due to the contamination of infected people and objects with infected materials that spread across the world.Main body: Human COVID-19 infection symptoms can range from being asymptomatic to being fatal, including respiratory failure, multiple organ dysfunction, and death. Large-scale genetic association studies have demonstrated that immune system components such as interferons, interleukins, toll-like receptors, and human leukocyte antigen as well as COVID-19 receptor variations (angiotensin-converting enzymes, transmembrane serine protease-2) are important host determinants of COVID-19 severity. Conclusion: The current review aims to demonstrate the human genetic factors that affect COVID-19 severity. | ||
| Keywords | ||
| COVID-19; Human genetic factors; Angiotensin-converting enzyme; severity; risk factors; miRNA | ||
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