EFFECT OF ETHANOLIC DATURA LEAVES EXTRACT ON STERILANT OF WHITE NORWAY RAT, RATTUS NORVEGICUS | ||
| Menoufia Journal of Plant Protection | ||
| Article 2, Volume 40, Issue 2, April 2015, Pages 483-489 PDF (465.88 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjapam.2015.323713 | ||
| Author | ||
| A. A. Mourad | ||
| Plant protection Research Institute, Agric. Res. Center, Egypt | ||
| Abstract | ||
| Abstract: The effect of ethanolic Datura leave extract, Datura stramonium, was studied on the fertility of albino rat males and teratogenic effect on the pregnant female of white Norway rat, Rattus norvegicus. Results showed that LD50 values were 116.70 mg/kg body weight. The results cleared that the treatment of male albino rats with sub-lethal doses (1/10 and 1/4 LD50) of tested extract decreased the pregnancy rate and also reduced the weight of males testes. Also, the obtained data from the treated pregnant female rats with the same sub-lethal doses have potential harmful effects on the fetuses in addition to fetal retardation of embryonic formation and development inside the uterus of the pregnant females especially in the first week followed by the second and third weeks. The resorption effects were observed inside the uterus of the pregnant female when compared with those of untreated pregnant females. Also, the tested plant extract reduced the number of newly born individuals and the weight of fetuses. | ||
| Keywords | ||
| Datura extract; sterilant- Rattus norvegicus | ||
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