Endotype Conformity with Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) Score in Chronic Rhinosinusitis | ||
| Egyptian Journal of Ear, Nose, Throat and Allied Sciences | ||
| Article 48, Volume 24, Issue 24, January 2023, Pages 1-7 PDF (376.03 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejentas.2023.185570.1600 | ||
| Authors | ||
| Iriana Maharani1; Finna Christianty* 2; Edi Handoko3; Nanik Setijowati4 | ||
| 1Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Brawijaya University/RSUD Dr. Saiful Anwar, Malang, Indonesia | ||
| 2Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Brawijaya University /Dr. Saiful Anwar General Hospital, Malang, Indonesia | ||
| 3Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Brawijaya University/Dr. Saiful Anwar General Hospital, Malang, Indonesia | ||
| 4Department of Public Health, Faculty of Medicine, Brawijaya University | ||
| Abstract | ||
| Introduction: Chronic rhinosinusitis (CRS) is one of the most prevalent disease entities in ORL-HNS field. Management strategy of CRS remains challenging among otorhinolaryngologist. Currently, CRS was known as a heterogeneous disease with various endotypes and phenotypes. By identifying endotypes, comprehensive management strategy in CRS was expected. The Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) score was a categorical score developed from Japan to diagnose eosinophilic chronic rhinosinusitis (eCRS) and non-eosinophilic chronic rhinosinusitis (non-eCRS). The assessment of JESREC score was expected to have conformity with CRS endotypes so that it can be used as future efficient diagnostic modality. Objective: This study aims to determine conformity and accuracy of endotype with JESREC score. Patients and Methods: An analytic study with a cross-sectional design involving 33 samples of primary CRS. Biomarker for specific endotypes measured by ELISA. Results: Statistical analysis with Mc. Nemar showed no difference/ a conformity between JESREC score and CRS endotypes (p>0.05) with sensitivity 61,5% and specificity 90%. Conclusion: JESREC score is considered a screening modality for CRS endotype | ||
| Keywords | ||
| Chronic rhinosinusitis; endotype; JESREC; phenotype | ||
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