Matar, H., Abdelazeim, E., Sheir, R., Nasser, M., Ahmed, M. (2023). Study the Correlation of Diabetic Complications and Macrophage Erythroblast Attacher (MAEA) rs6815464 Gene Polymorphism. test, 4(4), 94-104. doi: 10.21608/ejmr.2023.221674.1416
Hazem Samy Matar; Esraa Adel Abdelazeim; Rania El-Sayed Sheir; Mona Zaky sherif Nasser; Mahmoud Hassan Ahmed. "Study the Correlation of Diabetic Complications and Macrophage Erythroblast Attacher (MAEA) rs6815464 Gene Polymorphism". test, 4, 4, 2023, 94-104. doi: 10.21608/ejmr.2023.221674.1416
Matar, H., Abdelazeim, E., Sheir, R., Nasser, M., Ahmed, M. (2023). 'Study the Correlation of Diabetic Complications and Macrophage Erythroblast Attacher (MAEA) rs6815464 Gene Polymorphism', test, 4(4), pp. 94-104. doi: 10.21608/ejmr.2023.221674.1416
Matar, H., Abdelazeim, E., Sheir, R., Nasser, M., Ahmed, M. Study the Correlation of Diabetic Complications and Macrophage Erythroblast Attacher (MAEA) rs6815464 Gene Polymorphism. test, 2023; 4(4): 94-104. doi: 10.21608/ejmr.2023.221674.1416

Study the Correlation of Diabetic Complications and Macrophage Erythroblast Attacher (MAEA) rs6815464 Gene Polymorphism

Egyptian Journal of Medical Research
Volume 4, Issue 4, October 2023, Pages 94-104    PDF (628.89 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2023.221674.1416
Authors
Hazem Samy Matar1; Esraa Adel Abdelazeim* 1; Rania El-Sayed Sheir1; Mona Zaky sherif Nasser2; Mahmoud Hassan Ahmed1
1Internal Medicine department, Faculty of Medicine, Beni-Suef University, Egypt
2clinical pathology department, Faculty of Medicine, Beni-Suef University, Egypt
Abstract
This study was designed to evaluate MAEA gene rs6815464 polymorphism as a risk factor of type 2 diabetes mellitus (T2DM) associated  microangiopathic complications in the Egyptian population. Our patients were divided into two groups; diabetic patients with complications (30) recruited from Diabetes, endocrine and internal medicine clinic, Beni-Suef university hospital, compared with age and sex matched normal volunteers acting as a control group (61). Our study showed that diabetic retinopathy was the most common microangiopathic complication of T2DM (97%) followed by (90%) of the patients had diabetic nephropathy, while (70%) of the patients had diabetic neuropathy. Nonalcoholic fatty liver disease (NAFLD) was significantly higher in diabetic patients than in controls (p < 0.0001*). No significant correlation of MAEA rs6815464 polymorphism with the occurrence of diabetic microangiopathic complications was observed.
Keywords
Type 2 diabetes mellitus; Microangiopathy; MAEA gene rs6815464 polymorphism; NAFLD
References

  1. Filla LA, Edwards JL. (2016): Metabolomics in diabetic complications. Mol Biosyst ;12:1090–105.
  2. Solis-Herrera C, Triplitt C, Cersosimo E, et al. Pathogenesis of Type 2 Diabetes Mellitus. [Updated 2021 Sep 27]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
  3. Nangia V. ,Jonas JB. ,George R. (2018): Prevalence and causes of blindness and vision impairment: magnitude, temporal trends and projections in South and Central Asia Br. J Ophthalmol (2018).
  4. American Optometric Association (2019): Evidence-based Clinical Practice Guideline: Eye Care of the Patient With Diabetes Mellitus.Accessed May 2, 2019.
  5. Kittell F (2012): "Diabetes Management". In Thomas LK, Othersen JB (Eds.). Nutrition Therapy for Chronic Kidney Disease. Konstantinidis DG, Pushkaran S, Johnson JF, (2012): Signaling and cytoskeletal requirements in erythroblast enucleation. Blood. 2012;119(25):6118-6127.
  6. Donate-Correa, J.; Luis-Rodríguez, D.; Martín-Núñez, E.; Tagua, V.G.; Hernández-Carballo, C.; Ferri, C.; et al (2020): Inflammatory targets in diabetic nephropathy. J. Clin. Med. 2020, 9, 458.
  7. Malone, J. I. (2016). Diabetic central neuropathy: CNS damage related to hyperglycemia. Diabetes 65, 355–357. doi: 10.2337/dbi15-0034.
  8. Iqbal Z, Azmi S, Yadav R, Ferdousi M, Kumar M, Cuthbertson DJ (2018): Diabetic Peripheral Neuropathy: Epidemiology, Diagnosis, and Pharmacotherapy. Clin Ther. 2018;40(6):828–849.10.1016/j.clinthera.2018.04.001.
  9. Hanspal, M., Hanspal, J.S. (1994): The association of erythroblasts with macrophages promotes erythroid proliferation and maturation - a 30-kd heparin-binding protein is involved in this contact. Blood 84, 3494–3504.
  10. Mao, X., Shi, X., Liu, F., Li, G., Hu, L., (2013): Evaluation of erythroblast macrophage protein related to erythroblastic islands in patients with hematopoietic stem cell transplantation. Eur. J. Med. Res. 18, 9.
  11. Bala, S., Kumar, A., Soni, S., Sinha, S., Hanspal, M., (2006): Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division. Biochem. Biophys. Res. Commun. 342, 1040–1048.
  12. Cho, Y.S., Chen, C.H., Hu, C., Long, J., Ong, R.T., Sim, X. (2012): Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat. Genet. 44, 67–72.
  13. American Diabetes Association Professional Practice Committee; 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2022. Diabetes Care 1 January 2022; 45 (Supplement_1): S17–S38.
  14. Van Dieren S. , J.W. Beulens, Y.T. van der Schouw, D.E.Grobbee, B. Neal (2010): The global burden of diabetes and its complications: an emerging pandemic, Eur. J. Cardiovasc.Prev. Rehabil. 17 (Suppl. 1) (2010) S3–S8).
  15. Cho, Y.S., Chen, C.H., Hu, C., Long, J., Ong, R.T., Sim, X. (2012): Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat. Genet. 44, 67–72.
  16. Ramanathan RS (2017) Correlation of duration, hypertension and glycemic control with microvascular complications of diabetes mellitus at a tertiary care hospital. Integr Mol Med 4: DOI: 10.15761/IMM.1000272.
  17. Cho, Y.S., Chen, C.H., Hu, C., Long, J., Ong, R.T., Sim, X. (2012): Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat. Genet. 44, 67–72.
  18. Gastaldelli A, Cusi K. From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options. JHEP Rep. 2019 Jul 19;1(4):312-328. doi: 10.1016/j.jhepr.2019.07.002. PMID: 32039382; PMCID: PMC7001557.
  19. Hazlehurst JM, Woods C, Marjot T, Cobbold JF, Tomlinson JW. Non-alcoholic fatty liver disease and diabetes. Metabolism. 2016 Aug;65(8):1096-108. doi: 10.1016/j.metabol.2016.01.001. Epub 2016 Jan 11. PMID: 26856933; PMCID: PMC4943559.
  20. Zeid, Abdelmonem Fathy, Amira S. Ahmed, Mina Talaat Shohdy and Mostafa Mohamed Hamdy Asssy. “Evaluation of Bone Mineral Density among type 2 Diabetes Mellitus Patients in Zagazig University Hospitals.” The Egyptian Journal of Hospital Medicine 80 (2020): 599-607.
Statistics
Article View: 162
PDF Download: 138