Association between GCF Sclerostin Level and Haemoglobin A1c in Stage III Periodontitis Patients with Controlled and Uncontrolled Type 2 Diabetes Mellitus: A Case-Control Study | ||
| Advanced Dental Journal | ||
| Volume 5, Issue 4, October 2023, Pages 910-918 PDF (467.72 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/adjc.2023.238419.1398 | ||
| Authors | ||
| Aya Ali Hussien* 1; Ebtehal Mohammed2 | ||
| 1Oral Medicine and Periodontology Department, Egyptian Russian University, Cairo, Egypt. | ||
| 2Oral Medicine and Periodontology Department, Faculty of Dentistry, Beni-Suef University, Beni-Suef, Egypt. | ||
| Abstract | ||
| Aim: The aim of this study was to investigate the association between sclerostin level in gingival crevicular fluid and glycosylated haemoglobin in stage III periodontitis in non-diabetic, controlled and uncontrolled diabetic patients. Methods: 36 patients were included in this study. They were diagnosed as stage III periodontitis according to new classification of periodontal and peri-implant diseases diseases 2017. Patients were categorized into three groups with 12 patients for each group; group I (non -diabetic), group II (controlled diabetic) and group III (uncontrolled diabetic patients). Gingival crevicular fluid samples were collected from the site with greatest clinical attachment loss of each patient and sclerostin concentration was assessed by enzyme-linked immunosorbent assay. Results: There was no significant difference between sclerostin concentration in gingival crevicular fluid of three groups with highest concentration was in controlled diabetic patients. Also, there was no association between sclerostin concentration in gingival crevicular fluid and glycosylated haemoglobin in all study groups. Conclusion: Periodontitis was suggested to have more effect on sclerostin level than diabetes mellitus, which augment the evidence of sclerostin role in periodontitis destruction and recommended the anti-sclerostin antibody as a promising treatment for periodontitis. | ||
| Keywords | ||
| Sclerostin; GCF; HbA1c; diabetes mellitus; periodontitis | ||
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