Elbadr, M., Mohamed, E., Elsayed, H., Abdel-Rahman, M. (2023). THE POTENTIAL PROTECTIVE EFFECT OF STEVIA REBAUDIANA ON DEXAMETHASONE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS: ROLE OF PPAR-. test, 46(2), 1341-1359. doi: 10.21608/bfsa.2023.327568
Mohamed M. Elbadr; Eman Mohamed; Hoda M. Elsayed; Mahran S. Abdel-Rahman. "THE POTENTIAL PROTECTIVE EFFECT OF STEVIA REBAUDIANA ON DEXAMETHASONE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS: ROLE OF PPAR-". test, 46, 2, 2023, 1341-1359. doi: 10.21608/bfsa.2023.327568
Elbadr, M., Mohamed, E., Elsayed, H., Abdel-Rahman, M. (2023). 'THE POTENTIAL PROTECTIVE EFFECT OF STEVIA REBAUDIANA ON DEXAMETHASONE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS: ROLE OF PPAR-', test, 46(2), pp. 1341-1359. doi: 10.21608/bfsa.2023.327568
Elbadr, M., Mohamed, E., Elsayed, H., Abdel-Rahman, M. THE POTENTIAL PROTECTIVE EFFECT OF STEVIA REBAUDIANA ON DEXAMETHASONE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS: ROLE OF PPAR-. test, 2023; 46(2): 1341-1359. doi: 10.21608/bfsa.2023.327568

THE POTENTIAL PROTECTIVE EFFECT OF STEVIA REBAUDIANA ON DEXAMETHASONE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS: ROLE OF PPAR-

Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 2, December 2023, Pages 1341-1359    PDF (1.46 M)
Document Type: Original Article
DOI: 10.21608/bfsa.2023.327568
Authors
Mohamed M. Elbadr1; Eman Mohamed* 2; Hoda M. Elsayed3; Mahran S. Abdel-Rahman1
1Department of Medical Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt Department of Pharmacology and Toxicology, College of Pharmacy, Sphinx University, New Assiut City, Assiut, Egypt
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sohag University,Sohag, Egypt.
3Department of Histology and Cell biology, Faculty of Medicine, Sohag University, Sohag, Egypt
Abstract
Background:  Currently, using medicinal herbs has a great interest in the treatment of nonalcoholic fatty liver disease (NAFLD). This study evaluated the impact of stevia on the hallmark signs of dexamethasone-induced NAFLD in rats. Methods: Group I: Negative control rats received 2 ml of vehicle carboxy methyl cellulose (CMC). Group II:  Rats received dexamethasone 8 mg/kg/day intraperitoneal for 6 days. Group III: Rats received oral stevia extract 400 mg/kg/day for 12 days. Group IV: Rats received dexamethasone + stevia extract. Serum ALT, AST, TC, TG and adiponectin were measured. MDA, GPx and TNF-α were estimated in liver homogenate.  Histopathological changes and PPAR-α expressions in the liver were evaluated. Results:  Dexamethasone caused a reduction in GPx and ADP levels with an elevation in ALT, AST, TC, TG, MDA and TNF-α. There was a decrease in immunostaining expression of liver PPAR-α. Stevia caused an improvement in liver enzymes, lipid profile, oxidative stress, TNF-α and adiponectin levels. Conclusion: Stevia provided some protection against dexamethasone-induced NAFLD.
Keywords
Dexamethasone; NAFLD; PPAR-α and Stevia
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