Jebur, H., Al saray, B., Idbeis, H., Akhter, J., Afzal, S., Khan, N., Abdelsalam, K., Qadim, W., Qaddorri, B., Muhaisen, B. (2023). LUNG HISTO-PATHOLOGICAL CHANGES AND SODS GENE EXPRESSION IN WISTER RATS EXPOSED TO CONVENTIONAL AND ELECTRONIC CIGARETTES. test, 46(2), 1429-1440. doi: 10.21608/bfsa.2023.327634
Hakim Bahlok Jebur; Baraa Abd Al-Kareem Al saray; Hasan Ikareim Idbeis; Juheb Akhter; Shekh Mohammad Afzal; Naushad Khan; Khloud Gamal Abdelsalam; Wassan Qasim Qadim; Ban H Qaddorri; Ban Alaa Muhaisen. "LUNG HISTO-PATHOLOGICAL CHANGES AND SODS GENE EXPRESSION IN WISTER RATS EXPOSED TO CONVENTIONAL AND ELECTRONIC CIGARETTES". test, 46, 2, 2023, 1429-1440. doi: 10.21608/bfsa.2023.327634
Jebur, H., Al saray, B., Idbeis, H., Akhter, J., Afzal, S., Khan, N., Abdelsalam, K., Qadim, W., Qaddorri, B., Muhaisen, B. (2023). 'LUNG HISTO-PATHOLOGICAL CHANGES AND SODS GENE EXPRESSION IN WISTER RATS EXPOSED TO CONVENTIONAL AND ELECTRONIC CIGARETTES', test, 46(2), pp. 1429-1440. doi: 10.21608/bfsa.2023.327634
Jebur, H., Al saray, B., Idbeis, H., Akhter, J., Afzal, S., Khan, N., Abdelsalam, K., Qadim, W., Qaddorri, B., Muhaisen, B. LUNG HISTO-PATHOLOGICAL CHANGES AND SODS GENE EXPRESSION IN WISTER RATS EXPOSED TO CONVENTIONAL AND ELECTRONIC CIGARETTES. test, 2023; 46(2): 1429-1440. doi: 10.21608/bfsa.2023.327634

LUNG HISTO-PATHOLOGICAL CHANGES AND SODS GENE EXPRESSION IN WISTER RATS EXPOSED TO CONVENTIONAL AND ELECTRONIC CIGARETTES

Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 2, December 2023, Pages 1429-1440    PDF (1.22 M)
Document Type: Original Article
DOI: 10.21608/bfsa.2023.327634
Authors
Hakim Bahlok Jebur* 1; Baraa Abd Al-Kareem Al saray2; Hasan Ikareim Idbeis3; Juheb Akhter4; Shekh Mohammad Afzal4; Naushad Khan5; Khloud Gamal Abdelsalam6; Wassan Qasim Qadim3; Ban H Qaddorri3; Ban Alaa Muhaisen3
1pharmacology and toxicology-collage of medicine- Wasit university
2Department of Pharmacology, College of Medicine, Wasit University, Iraq
3Department of Microbiology, College of Medicine, Wasit University, Iraq
4Department of Medical Elementology & Toxicology, School of Chemical and Life Science, Jamia Hamdard, New Delhi -110062
5Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India
6Department of Biochemistry, Faculty of Science, Damanhour University, Egypt
Abstract
Background: With the rapid increase in the use of electronic cigarettes as a prevalent form of nicotine, numerous studies have reported that their use has potentially negative health effects. Objectives: Evaluate and compare the effects of electronic cigarettes and traditional cigarettes on lung tissue. Study Design and Methodology: Twenty-five male Wistar rats were split into three groups: the EC Group was treated to e-cigarette liquid vapor, the CC Group to conventional smoke, and the control group without nicotine. Result: Significant alterations were observed in both experimental groups., including an increase in thickness of the alveolar wall, infiltration of inflammatory cells, collapsed vacuole in the wall of alveoli, and focal infiltration of lymphocytes in the wall of the bronchiole. Additionally, there was up-regulation of SODs gene expression in both groups. Conclusion: Histo-pathological analysis suggests that smoking and vaping are equally harmful to lung tissue. Real-time PCR analysis revealed significant up-regulation of SODs gene expression in conventional cigarettes and electronic cigarettes compared to the control group
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