Potential effects of onion skin, banana peel and apricot kernel powders on hepatotoxicity induced by carbon tetrachloride in rats | ||
| مجلة کلية التربية النوعية - جامعة بورسعيد | ||
| Article 14, Volume 20, Issue 20, April 2023 | ||
| Document Type: المقالة الأصلية | ||
| DOI: 10.21608/pssrj.2023.184358.1216 | ||
| Authors | ||
| هدير عبد المنعم عطا* 1; عبير السيد حسن الخميسى2; سارة أحمد سيد أحمد3; يوسف عبد العزيز الحسانين4 | ||
| 1جامعة بورسعيد علية التربية النوعية | ||
| 2قسم الاقتصاد المنزلي - کلية التربية النوعية جامعة بورسعيد - بور سعيد - مصر | ||
| 3قسم الاقتصاد المنزلي ،کلية التربية النوعية ،جامعة بورسعيد | ||
| 4کلية الاقتصاد المنزلى - جامعة المنوفية | ||
| Abstract | ||
| Liver diseases are among the most challenging healthcare problems worldwide. Thus, there has been a need to explore alternative therapies to chemotherapy drugs that have long been used to treat liver patients, the use of which has been associated with many side effects, in addition to the significant financial cost, which often leads to patient non-compliance. This study was conducted to explore the Effect of three plant parts that result as wastes from food processing, namely red onion skin, banana peels and apricot kernel powders, on hepatotoxicity induced by carbon tetrachloride in rats. Compared with the normal control group rats, the CCl4 treated rats showed significant (p≤0.05) decreases in different biological parameters, including BWA, FI and FER, by the rate of -35.16, -33.31 and -31.08%, respectively. Also, biochemical parameters such as serum liver enzyme activities AST, ALT and ALP were significant (p≤0.05) elevated by the rate of 107.92, 102.71 and 135.64%, respectively. For immunological parameters, Alb was significant (p≤0.05), decreased by -37.61, and TNF-α increased by 102.84%. Also, oxidative stress is recorded in the blood through a decrease in the level of antioxidants (GSH and GSSG) and increased oxidants (MDA and NO2). All of those parameters indicated liver injuries by CCl4. Whereas animals treated with the selected plant parts (red onion skin powder, ROSP, banana peel powder, BBP, apricot kernel powder, AKP and their mixture) showed significant (p≤0.05) improvements in all previous biological, biochemical, and immunological parameters as well as reduce the oxidative stress markers which indicating the protection against hepatic cell damage. The highest amelioration effects against CCl4-induced hepatotoxicity were recorded in rats treated with a mixture of plant parts, followed by ROSP, BPP and AKP groups, respectively. In conclusion, the selected plant parts effectively protected against CCl4-induced hepatotoxicity. Therefore, we recommended powders of these plant parts in concentrations of up to 5% (w/w), an amount to be included in our daily live diets, drinks and food supplements. | ||
| Keywords | ||
| Liver functions; blood glucose; albumin; TNF-α; glutathione fractions; oxidative stress; malondialdehyde; nitric oxides | ||
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