Evaluating the bioactive compounds content, toxicological aspects and antibacterial/antifungal activities of the reishi mushroom (Ganoderma lucidum) ethanol extract | ||
| مجلة کلية التربية النوعية - جامعة بورسعيد | ||
| Article 13, Volume 20, Issue 20, April 2023 | ||
| Document Type: المقالة الأصلية | ||
| DOI: 10.21608/pssrj.2023.184359.1217 | ||
| Authors | ||
| أسماء ربيع علي* 1; عبير السيد حسن الخميسى2; يوسف عبد العزيز الحسانين3; نجلاء فتحي4 | ||
| 1جامعه بورسعيد كلية التربية النوعية | ||
| 2قسم الاقتصاد المنزلي - کلية التربية النوعية جامعة بورسعيد - بور سعيد - مصر | ||
| 3کلية الاقتصاد المنزلى - جامعة المنوفية | ||
| 4جامعه بورسعيد كليه تربيه نوعيه اقتصاد منزلي | ||
| Abstract | ||
| Reishi mushroom (Ganoderma lucidum, family Ganodermaceae) is spread worldwide and is widely used for several nutritional and medical purposes. Therefore, knowledge of all aspects of this mushroom's composition, toxicity and biological activities is required. The present study aims to determine the bioactive compound content, toxicity studies, and antibacterial/antifungal activities of Ganoderma lucidum ethanol extract (GLEE). Data on the nutrients composition of Ganoderma lucidum powder indicated that crude fiber and carbohydrates were the largest compounds (51.06 ± 2.42 and 36.17 ± 3.91%, respectively), followed by total protein (8.69 ± 0.69 %), ash (2.21 ± 0.14%) and crude fat (1.87 ± 0.20%.). Also, Furthermore, the nutraceuticals (bioactive compounds) content of GLEE indicated that terpenoids were the largest compound (241.47± 20.72 mg linalol.100 g-1) followed by polysaccharides (154.30± 19.06 mg starch equivalent.100 g-1), phenolics (49.98 ± 5.61 mg gallic acid equivalent.100g-1), triterpenoids (51.16 ± 6.49 mg ursolic acid.100 g-1). Furthermore, GL-EE recorded antibacterial and antifungal. On the other side, the toxicity studies of GL-EE were evaluated in Albino rats using standard methods. Various doses (2000 and 5000 mg/kg) of the extract were orally administered to rats and kept under close observation for the next 10 days. Data from the acute toxicity study did not show any toxicity signs and symptoms at doses 2000 mg/kg and 5000 mg/kg of GL-EE. Such signs and symptoms, including no morbidity or mortality, were observed. As a result, the LD50 of the Gl-EE could be greater than 5000mg/kg body weight. The effective biotransformation and elimination of this natural product within a short period. Therefore, the present study recommended that Ganoderma lucidum extract (GL-EE) could be used safely in different nutritional and medical applications. | ||
| Keywords | ||
| Chemical composition; bioactive compounds; acute toxicity; body weight; organs weight | ||
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