Biopharmacodynamical Effect of Clindamycin and Spectinomycin Combination in Experimentally E.Coli Infected Broilers | ||
| Scientific Journal of October 6 University | ||
| Article 1, Volume 2, Issue 2, July 2014, Pages 166-174 PDF (474.94 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/sjou.2014.32879 | ||
| Authors | ||
| Kadry Mohamed Sadek1; Hazem Mohammed Shaheen2 | ||
| 1Department of Biochemistry, Faculty of Vet. Med., Damanhour University, Damanhour, Egypt. | ||
| 2Department of Pharmacology, Faculty of Vet. Med., Damanhour University, Damanhour, Egypt. | ||
| Abstract | ||
| Antimicrobials are co-administered frequently worldwide in medical as well as veterinary practices. Often, the therapeutic efficiency of two antimicrobial drugs may induce adverse effects. In this study, the possibility of a clindamycin/spectinomycin interaction effect and the efficacy of the combination were investigated in 23 day-old chickens experimentally infected with E. coli. The challenged chickens were orally treated with Clindamycin (11mg/ kg body weight) or spectinomycin (51.1 mg/L) for 5 successive days with a combination of both drugs at therapeutic and half-therapeutic doses. Two blood samples were collected from five chickens of each group on the 4th day during the treatment course and on the 2nd, 7th, 14th and 21st days post-treatment. The results revealed that co-administration of clindamycin/spectinomycin reduced the severity of clinical signs and altered the biochemical function parameters related to liver, kidney and of oxidative stress. The effect of both drugs was short-lived, and most of the parameters returned to normal within 2 weeks after administration of them. It is concluded that, the therapeutic doses co- administration of clindamycin/spectinomycin reduced the severity of E. coli infection clinical signs and showed significant alterations in some liver and kidney function parameters as well as oxidative stress. This effect is short-lived and most of the parameters went back to normal within 2 weeks post drug(s) administration. | ||
| Keywords | ||
| biochemical; Clindamycin; Bpectinomycin; Broilers; Escherichia coli | ||
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