Presepsin as an early diagnostic marker in Premature infants with neonatal sepsis and septic shock | ||
| Benha Medical Journal | ||
| Article 1, Volume 41, Issue 2, May and June 2024, Pages 1-13 PDF (877.95 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2023.245353.1940 | ||
| Authors | ||
| Ashraf Mohamed Shahin1; Omima mohamed Abdel Haie1; Sahar Mohamed Fayed2; Rime Ahmed Abdelsalam* 3 | ||
| 1Professor of Pediatrics, Faculty of Medicine, Benha University | ||
| 2Professor of Clinical Pathology, Faculty of Medicine, Benha University | ||
| 3Department of Pediatrics Faculty of Medicine, Benha University | ||
| Abstract | ||
| Background: Neonatal sepsis is a systemic condition involving hemodynamic changes and clinical manifestations caused by bacterial, viral, or fungal infection that occurs within the first 28 days of life. This study aimed to assess the accuracy of Presepsin for diagnosis and early detection of sepsis and septic shock among preterm neonates. Methods: This Cross-sectional study included 75 preterm neonates with symptoms suspicious of sepsis. The classified into 3 groups: Group 1: Infection (suspected infection not meeting the criteria for sepsis). Group 2: Sepsis (neonatal systemic inflammatory response syndrome, SIRS, plus suspected or proven infection). Group 3: Septic shock (sepsis plus cardiovascular organ dysfunction). Detailed history, clinical examination, laboratory investigations: Complete blood picture (CBC), C-Reactive Protein (CRP), blood culture and determination of Human Presepsin level in the Blood (PSEP). Results: Presepsin level was significantly lower at D3 and D5 compared to D1 (P | ||
| Keywords | ||
| Presepsin; Premature infants; neonatal sepsis; septic shock | ||
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