Association of IL-6 rs1800795 and IL-1 β rs16944 polymorphisms with non-small cell lung cancer in the Egyptian population: a pilot study | ||
| Scientific Journal for Damietta Faculty of Science | ||
| Volume 13, Issue 3, December 2023, Pages 8-15 PDF (423.15 K) | ||
| Document Type: Original articles | ||
| DOI: 10.21608/sjdfs.2023.248290.1144 | ||
| Authors | ||
| Yomna Fawzy Metwally* 1; Rasha Fikry Zahran2; Rana Ramzy Elsadda2; Sherif Refaat3; Afaf Mohammed Elsaid4 | ||
| 1Biochemistry Department, Faculty of Science, Damietta University, Damietta, Egypt. | ||
| 2Biochemistry Department, Faculty of Science, Damietta University, Damietta, Egypt | ||
| 3Oncology Department, Oncology Center, Mansoura University, Mansoura, Egypt. | ||
| 4Genetics Unit, Children Hospital, Mansoura University, Mansoura, Egypt. | ||
| Abstract | ||
| Lung cancer is a serious health and life issue, with the highest rates of incidence and mortality in the world. It is now clear that inflammation is a key factor involved in all aspects of carcinogenesis, notably lung cancer development. Genetic changes, including polymorphisms in inflammatory genes, are supposed to play a significant role in increasing lung cancer risk. In this study, we aim to investigate the association of IL-6 rs1800795 and IL-1β rs16944 polymorphisms with non-small cell lung cancer (NSCLC) development in the Egyptian population. The study design was composed of 100 NSCLC cases and 100 controls, which were genotyped using the ARMS-PCR technique, electrophoresed on a 2.5% agarose gel, and visualized using ethidium bromide under ultraviolet illumination. The IL-1β rs16944 genotypes were significantly different in NSCLC patients as compared to healthy controls (p = 0.032). Whereas the genotypes and alleles of the IL-6 rs1800795 were not significantly linked to NSCLC incidence (p = 0.726; p = 0.822, respectively). To our best knowledge, this study aimed to uncover the great impact of IL-1β rs16944 genotypes on NSCLC development in the Egyptian population; thus, it may be a gateway for earlier NSCLC prevention. | ||
| Keywords | ||
| Lung cancer; polymorphism; IL-6; IL-1β Egypt | ||
|
Statistics Article View: 115 PDF Download: 145 |
||
