Clinico-Pathological Features of Breast Cancer and Impact on Survival in Elderly Patients | ||
| SECI Oncology Journal | ||
| Volume 11, Issue 4, October 2023, Pages 333-338 | ||
| Abstract | ||
| Background: Breast carcinoma is one of the most commonly identified cancers in women worldwide, the 5th reason of cancer-related deaths and commonly affecting older Egyptian females. Aim: To explore the clinical and pathological characteristics of breast cancer in elderly women and impact on survival. Methods: A retrospective study was performed based on medical records of females who were treated in National Cancer Institute, Cairo University, Zagazig University Hospitals, and Meet-Ghamr Oncology Center in the period between January 2012 and December 2016. Results: The study included 343 breast cancer patients whose age ranging between 65 and 80 years with mean age 68.8 years. About 85.1% of the studied cases had no family history of breast carcinoma and 82.8% of them had negative history of taking oral contraceptive pills (OCP). Associated co-morbidities were noticed in 57.4% of this group. Our group tends to present with clinical stage II and III (44.8%), (34%) respectively, with lymph node involvement in (56.6%) of cases and high percentage of hormone expression [ER-positive (79.6%), PRpositive (76.4%)] while lower frequency to be HER-2 positive (15.5%). Most of cases (88%) underwent upfront surgery, modified radical mastectomy (MRM) was the main procedure. The overall survival (OS) rate for the whole study group at 5 years was 70.7% with median OS 87.1 months, while the DFS rate at 5 years was 81.6% after exclusion of the 21 patients who had metastasis at diagnosis. Expression of ER and PR was related with better survival. Conclusion: Breast cancer in elderly patients in our study tends to be diagnosed at a later stage with best outcome with hormone receptor positive women and further studies are needed to evaluate better management. | ||
| Keywords | ||
| breast cancer; elderly patients; survival; adjuvant | ||
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