PYRIDINE DERIVATIVES AS ANTICANCER AGENTS: FDA-APPROVED DRUGS AND PROMISING REPORTED COMPOUNDS | ||
| Al-Azhar Journal of Pharmaceutical Sciences | ||
| Volume 68, Issue 2, September 2023, Pages 64-81 PDF (602.62 K) | ||
| DOI: 10.21608/ajps.2023.332167 | ||
| Authors | ||
| Mohamed Ayman ALy El-Zahabi* 1; Reda G Yousef2; Ibrahim H Eissa2; Alaa Elwan2 | ||
| 1Al Mockhaim Al Daem street, Nasr 6thdistrict, Cairo Egypt | ||
| 2Department of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo11884, Egypt. | ||
| Abstract | ||
| Pyridine derivatives are a family of heterocyclic nitrogenous compounds possessing many of applications in the discovery of anticancer drug. This synthetic category serve as the potent class of compounds in the treatment of many types of tumors as breast cancer, myeloid leukemia, pancreatic cancer, liver cancer. In this review, the recent results of the published studies about pyridine derivatives were reported. In addition, the most promising candidates in each work was focused mentioning it anticancer activity compared to the reference molecules. This work may serve as a collection of promising candidates for further design and synthesis of anti-cancer agents. | ||
| Keywords | ||
| Pyridine derivative; Anti-cancer agents; Biological targets | ||
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