Association between Helicobacter pylori and Autoimmune Diseases Involving Type 1 Diabetes Mellitus and Autoimmune Thyroiditis | ||
| Egyptian Journal of Medical Microbiology | ||
| Volume 33, Issue 1, January 2024, Pages 129-136 PDF (398.13 K) | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2024.332174 | ||
| Authors | ||
| Essraa A. Hegazy* 1; Rania Talaat2 | ||
| 1Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt | ||
| 2Medical Microbiology and Immunology Department, Faculty of Medicine, Helwan University, Cairo, Egypt | ||
| Abstract | ||
| Background: Since the discovery of the harmful effects of Helicobacter pylori (H. pylori) and its initial discovery in the stomach, contemporary gastroenterology has made significant advancements. Epidemiological statistics indicate that autoimmune illnesses are more common when certain bacteria are infective or afterward. Studies have shown that H. pylori may be linked to different autoimmune disorders and that it may be a trigger for stomach autoimmunity. This study examines the current evidence supporting or refuting the theory that H. pylori may be a triggering factor for autoimmune disorders, such as type 1 diabetes mellitus and autoimmune thyroiditis. Methodology: Our study involved 180 participants divided into three equal groups including healthy control subjects, type 1 diabetes mellitus patients and autoimmune nondiabetic thyroid cases. All groups were subjected to blood sampling for measurement of Glycated hemoglobin A1c, thyroid stimulating hormone (TSH), free thyroxine (FT4), anti-H. pylori antibodies and cytokines multiplex test including IL-2, IL 18, and IFN gamma. Result: Serum IgG anti-H. pylori antibodies, IL 18, IFNγ levels showed higher levels while serum IL 2 level showed lower levels in autoimmune patients. Conclusions: Based on the aforementioned study, we conclude that H. pylori infection is one of the main environmental factors that contribute to multiple autoimmune illnesses. | ||
| Keywords | ||
| Helicobacter pylori- autoimmune disease- Type 1 Diabetes Mellitus – autoimmune thyroiditis; cytokines | ||
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