Roles and applications of miRNAs in diagnosis, treatment, prognosis, and control of parasitic diseases. Part I: Helminthes | ||
| Parasitologists United Journal | ||
| Article 1, Volume 16, Issue 3, December 2023, Pages 154-170 PDF (521.14 K) | ||
| Document Type: Review Article | ||
| Authors | ||
| Sherif Abaza* ; Wafaa Zaki | ||
| Department of Medical Parasitology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||
| Abstract | ||
| In the past two decades, the role of non-coding RNAs (ncRNAs) in inflammation gained much attention for their modification of inflammatory gene expression. They accordingly serve as diagnostic and/or prognostic biomarkers as well as potential therapeutic targets and vaccine candidates in various inflammatory diseases. These small (18-25 nucleotides) double-stranded ncRNA, microRNA (miRNA) are highly conserved occurring naturally in all eukaryotic genomes. They target specific messenger RNAs (mRNAs) to regulate their post-transcriptional expression resulting in translation suppression and gene silencing. Therefore, they act as master regulators of gene expression in homeostasis and disease. Proved evidences showed that all eukaryotes selectively sort miRNAs into extracellular vesicles (EVs) for secretion to nearby or distant targets. Besides, recent studies validated the ncRNAs role in RNA maturation, protein synthesis and post-translational pathway of autophagy. The aim of the present review is to understand ncRNAs functional roles with special emphasis on miRNAs and their potential applications in Parasitology research, as well as the effects of human miRNAs in host-parasite interactions. | ||
| Keywords | ||
| diagnostic biomarkers; drug targets; extracellular vesicles; helminths; miRNAs; prognostic assessment; vaccine candidates | ||
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