Nachate, S., El Mouhtadi, M., Zouine, Y., Haouane, M., Azami, M., Saiad, M., Basraoui, D., Jalal, H., Nassih, H., Elqadiry, R., Bourrahouat, A., Sab, I., El Hakkouni, A. (2023). Secondary cutaneous aspergillosis in a child with Behçet’s disease: a case-based update. test, 19(1), -. doi: 10.1186/s43159-023-00242-2
Soumia Nachate; Mouad El Mouhtadi; Yousra Zouine; Mohamed Amine Haouane; Mohamed Amine Azami; Mohamed Oulad Saiad; Dounia Basraoui; Hicham Jalal; Houda Nassih; Rabiy Elqadiry; Aicha Bourrahouat; Imane Ait Sab; Awatif El Hakkouni. "Secondary cutaneous aspergillosis in a child with Behçet’s disease: a case-based update". test, 19, 1, 2023, -. doi: 10.1186/s43159-023-00242-2
Nachate, S., El Mouhtadi, M., Zouine, Y., Haouane, M., Azami, M., Saiad, M., Basraoui, D., Jalal, H., Nassih, H., Elqadiry, R., Bourrahouat, A., Sab, I., El Hakkouni, A. (2023). 'Secondary cutaneous aspergillosis in a child with Behçet’s disease: a case-based update', test, 19(1), pp. -. doi: 10.1186/s43159-023-00242-2
Nachate, S., El Mouhtadi, M., Zouine, Y., Haouane, M., Azami, M., Saiad, M., Basraoui, D., Jalal, H., Nassih, H., Elqadiry, R., Bourrahouat, A., Sab, I., El Hakkouni, A. Secondary cutaneous aspergillosis in a child with Behçet’s disease: a case-based update. test, 2023; 19(1): -. doi: 10.1186/s43159-023-00242-2

Secondary cutaneous aspergillosis in a child with Behçet’s disease: a case-based update

Annals of Pediatric Surgery
Volume 19, Issue 1, January 2023    PDF (2.16 M)
DOI: 10.1186/s43159-023-00242-2
Authors
Soumia Nachate* ; Mouad El Mouhtadi; Yousra Zouine; Mohamed Amine Haouane; Mohamed Amine Azami; Mohamed Oulad Saiad; Dounia Basraoui; Hicham Jalal; Houda Nassih; Rabiy Elqadiry; Aicha Bourrahouat; Imane Ait Sab; Awatif El Hakkouni
Abstract
Background
Invasive aspergillosis (IA) is one of the rarest opportunistic fungal infections and has increased in frequency worldwide in recent years. It is a life-threatening infection associated with high mortality rates. Invasive pulmonary aspergillosis (IPA) is the most severe form of the disease. Extrapulmonary forms can develop as a primary infection or occur as part of a disseminated infection from the lung in severely immunocompromised patients. The major limitation in the management of these infections is the challenge of early diagnosis.
Case presentation
Here we report a case of secondary cutaneous aspergillosis that developed from extensive pulmonary aspergillosis in a 3-year-old female who underwent immunosuppressive therapy for a diagnosed Behçet disease (BD). hyphae were identified on skin biopsies. Cultures grew . The diagnosis of cutaneous aspergillosis enabled us to diagnose IPA, although there was no mycopathological proof of lung infection. The patient was successfully treated with voriconazole (8 mg/kg/day) and surgical debridement of the skin lesion.
Conclusions
Although cutaneous involvement in aspergillosis is extremely uncommon, it may be the presenting feature in some cases, allowing for an accurate and timely diagnosis of deeply infected sites. Accordingly, when evaluating skin lesions in immunocompromised individuals, especially debilitated children with underlying diseases requiring long-term immunosuppressive agents, cutaneous aspergillosis should be vigilantly considered.
Keywords
Behçet disease; Invasive pulmonary aspergillosis; Cutaneous aspergillosis; immunosuppressants
Statistics
Article View: 97
PDF Download: 64