Effect of Paracetamol administration on the Rat kidney structure: A Morphological Study | ||
| Zagazig University Medical Journal | ||
| Article 93, Volume 27, Issue 4, July 2021, Pages 567-576 PDF (1.13 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2019.11494.1194 | ||
| Authors | ||
| Abdelmonem Hegazy1; Enssaf Ahmad Abd Al Hameed2; Dalia El-Wafaey1; Omnia Khorshed* 3 | ||
| 1Human Anatomy & Embryology department, Faculty of Medicine-Zagazig University | ||
| 2Human Anatomy & Embryology department, Faculty of Medicine- Zagazig University | ||
| 3Anatomy and Embryology department, Faculty of medicine , Zagazig university. | ||
| Abstract | ||
| Aims: To clarify the nephrotoxic effect of paracetamol in adult male albino rats. Methodology: In this study, fourteen adult male albino rats were divided equally into two groups; Control group and paracetamol-treated group. Kidney specimens were processed for biochemical and histological analysis. Results: Administration of paracetamol revealed a noticeable deterioration of both biochemical and histological changes detected in the paracetamol-treated group. The biological changes were in the form of a significant increase in serum urea and creatinine levels. The histological changes markedly affected the tubular system; the proximal and distal convoluted tubules showed marked degeneration, dense nuclear staining, cytoplasmic vacuolization and partial loss of the brush borders. Most tubules were dilated, irregular and were filled with hyaline casts. Conclusion: Paracetamol made biochemical and histopathological changes in the rat's kidneys. These findings revealed that this nephrotoxicity was associated with an increase in oxidative damage and apoptosis. Keywords: Paracetamol, Nephrotoxicity, Albino Rats | ||
| Keywords | ||
| Paracetamol; Nephrotoxicity; albino rats | ||
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