Evaluation of Adjunctive Subconjunctival Injection of Bevacizumab before Pterygium Surgery | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 51, Volume 94, Issue 1, January 2024, Pages 343-351 PDF (391.67 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2024.337176 | ||
| Abstract | ||
| Background: Pterygium is a common ocular surface lesion involves the bulbar conjunctiva's fibrovascular expansion onto the cornea. The exact cause of pterygium remains unclear, however exposure to ultraviolet radiation is recognized as a significant contributing element. The development of pterygium is believed to involve vascular endothelial growth factor (VEGF). Bevacizumab, a monoclonal antibody, functions by attaching to and blocking VEGF. Aim of study: This study aimed to assess the effectiveness and safety of preoperative subconjunctival bevacizumab for primary pterygium excision. Patients and methods: This prospective study included 30 patients with primary pterygium attending the Ophthalmology Outpatient Clinic, Al-Azhar University Hospital, Assiut, Egypt. Patients were divided into two groups: Group “A” (15 patients) received subconjunctival injection of 2.5 mg bevacizumab 1 week before surgical excision of the pterygium with conjunctival autograft transplantation. Group “B” (15 patients) underwent pterygium excision with conjunctival autograft transplantation without injection of bevacizumab. Patients were followed up for 6 months. Results: In group “A”, 14 out of 15 patients (93.3%) showed no recurrence after bevacizumab injection and pterygium surgery. One patient (6.7%) had recurrence. In group “B”, 6 out of 15 patients (40%) had recurrence after pterygium surgery without bevacizumab injection. The recurrence rate was significantly lower in the bevacizumab injection group compared to control group (p=0.031). No complications were observed with subconjunctival bevacizumab injection. Conclusion: Subconjunctival injection of bevacizumab before surgical excision of primary pterygium is safe and effective in reducing the recurrence rate. | ||
| Keywords | ||
| Pterygium; Bevacizumab; Vascular endothelial growth factor; Recurrence | ||
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