Value of qPET in Pediatric Patients with Hodgkin Lymphoma | ||
| SECI Oncology Journal | ||
| Volume 12, Issue 1, January 2024, Pages 23-28 | ||
| Abstract | ||
| Introduction: qPET is a semi-automatic quantitative measurement used to assess the positron emission tomography (PET) response in lymphoma. The aim of this study was to compare qPET and the Deauville score (DS) and find their concordance in childhood Hodgkin lymphoma (HL) patients treated with the Euronet protocol at the Children Cancer Hospital Egypt (CCHE). Materials and Methods: qPET is computed by dividing the peak standardized uptake value (SUV) of the hottest residual uptake by the mean SUV of the liver. Interim PET (iPET) will be evaluated in accordance with qPET and Deauville score (DS). Results: We retrospectively analyzed 424 pediatric patients with HL, with a mean age of 10.1 (2-18) years. Based on iPET measurements, DS1was identified in 24 patients, DS2 in 106 patients, DS3 in 187 patients, DS4 in 77 patients, and DS5 in 30 patients. 317 patients were negative (DS 1-3), while 107 were positive (DS 4-5). qPET revealed that 341 patients were negative (<1.3), and 83 were positive (≥1.3). We found that 25 patients had a DS 4 (positive) and a qPET 3 (negative), out of these patients, two experienced a relapse, while the remaining twenty-three patients were in complete remission. The overall survival (OS) and Event free survival (EFS) for negative DS were 99.1% and 90.4%, respectively. Similarly, for negative qPET, the OS and EFS were 99.2% and 88.3%, respectively. In contrast, the OS and EFS for positive DS were 95.3% and 80.1%, respectively, and for positive qPET, they were 94.4% and 83.9%. Conclusion: Our qPET results indicate that it is a suitable semi-automatic quantitative method for evaluating response in pediatric HL patients treated with the Euronet protocol. | ||
| Keywords | ||
| qPET; pediatric; Hodgkin Lymphoma; response; interim PET | ||
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