Prevalence and Risk Factors of Cardiotoxicity in Elderly Cancer Patients | ||
| The Egyptian Journal of Geriatrics and Gerontology | ||
| Volume 10, Issue 2, October 2023, Pages 100-112 PDF (445.75 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejgg.2023.338567 | ||
| Authors | ||
| Maha A.Ali* 1; Hala Samir Sweed2; Mohamed Ahmed Alsadany2; Ghada Kazamel3; Mohamed F.Tolba4 | ||
| 1Dar El-Salam Oncology Center, Cairo, Egypt | ||
| 2Department of Geriatrics and Gerontology, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||
| 3Department of Cardiology, National Heart Institute, Ministry of Health, Giza, Egypt | ||
| 4Geriatrics and Gerontology Department, Faculty of Medicine, Ain Shams University. Geriatric Palliative Care Unit, Ain Shams University Hospitals, Cairo, Egypt. | ||
| Abstract | ||
| Background: Cancer and heart disease are the leading causes of death in older adults. Cardiotoxicity of anticancer agents may lead to under-treatment of elderly patients, resulting in suboptimal outcomes. Aim: To determine the prevalence and risk factors of cardiotoxicity in elderly patients with cancer. Patients and Methods: The study sample included one hundred (100) elderly subjects, both males and females, aged sixty years and above. The study participants were subjected to the following: comprehensive geriatric assessment (CGA), laboratory work-up (fasting blood glucose, lipid profile, and C-reactive protein), electrocardiography (ECG), and echocardiography (ECHO). Results: The prevalence of cardiotoxicity (any pattern) was 57%. Patients who experienced cardiotoxicity were older, and had higher smoking index, lower body mass index, and longer cancer duration. They had a higher prevalence of hypertension, diabetes, and dyslipidemia and had higher mean levels of C-reactive protein. Participants who had received certain chemotherapeutic agents (e.g., Anthracycline), certain targeted therapy agents (e.g., Pertuzumab); and those who received radiotherapy (delivered to the chest) were more liable for cardiotoxicity. Cardiotoxicity was associated with malnutrition, depression and functional decline in the affected patients. Conclusion: Cardiotoxicity is common in elderly patients with cancer. It is associated with certain risk factors; such as smoking, dyslipidemia, hyperglycemia, malnutrition and certain anticancer treatments. Comprehensive geriatric assessment is essential in the management of elderly cancer patients. | ||
| Keywords | ||
| Cancer; Cardiovascular; Anticancer Agents; Cardiotoxicity; Elderly | ||
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