Darwish, R., Hammoda, H., Harraz, F., Shawky, E. (2024). Genus Thuja: A comprehensive review on botany, traditional uses, pharmacological activities and phytochemistry. test, 1(1), 100-120. doi: 10.21608/japs.2024.249826.1000
Reham S Darwish; Hala Hammoda; Fathallah M Harraz; Eman Shawky. "Genus Thuja: A comprehensive review on botany, traditional uses, pharmacological activities and phytochemistry". test, 1, 1, 2024, 100-120. doi: 10.21608/japs.2024.249826.1000
Darwish, R., Hammoda, H., Harraz, F., Shawky, E. (2024). 'Genus Thuja: A comprehensive review on botany, traditional uses, pharmacological activities and phytochemistry', test, 1(1), pp. 100-120. doi: 10.21608/japs.2024.249826.1000
Darwish, R., Hammoda, H., Harraz, F., Shawky, E. Genus Thuja: A comprehensive review on botany, traditional uses, pharmacological activities and phytochemistry. test, 2024; 1(1): 100-120. doi: 10.21608/japs.2024.249826.1000

Genus Thuja: A comprehensive review on botany, traditional uses, pharmacological activities and phytochemistry

Journal of Advanced Pharmaceutical Sciences
Volume 1, Issue 1, January 2024, Pages 100-120    PDF (1.54 M)
Document Type: Review Article
DOI: 10.21608/japs.2024.249826.1000
Authors
Reham S Darwish* ; Hala Hammoda; Fathallah M Harraz; Eman Shawky
Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Egypt.
Abstract
Thuja is one of Coniferous trees (family Cupressaceae). It comprises five species: Thuja occidentalis, Thuja koraiensis, Thuja plicata, Thuja standishii and Thuja sutchuenensis. This review aimed at gathering the botany, traditional uses, biological activities and phytoconstituents of Thuja species from 1984 until 2020, as they are considered generous sources of numerous phytoconstituents that may be used as scaffolds for new drugs with diverse pharmacological activities.  Online bibliographies were searched using popular search engines, such as Google Scholar, PubMed, Springer, and Web of Science, in order to cover the botany, folk uses, biological activities and phytochemistry of Thuja plants. The review revealed that Thuja plants have diverse biological effects and economic and folk uses. Moreover, the review showed the different phytoconstituents classes in Thuja plants. It can be concluded that Thuja plants are good candidates for intensive research to prove their biological activities by in vivo and clinical trials in order to get evidence-based drugs and discover new drugs for the treatment of several ailments.
Keywords
Thuja species; Botanical description; Phytochemistry; Biological activities
References
  1. https://conifersociety.org/conifers/thuja/. 2020.
  2. Farjon A, Flier D. An Atlas of the World’s Conifers An Analysis of their Distribution, Biogeography, Diversity and Conservation Status. Leiden, Boston: Brill; 2013. 286 p.
  3. Chang LC, Song LLL, Park EJJ, Lumonadio L, Lee KJ, Farnsworth NR, et al. Bioactive constituents of Thuja occidentalis. J Nat Prod. 2000;63:1235–8.
  4. Naser B, Bodinet C, Tegtmeier M, Lindequist U. Thuja occidentalis (Arbor vitae): A Review of its Pharmaceutical, Pharmacological and Clinical Properties. Evidence-Based Complement Altern Med. 2005;2(1):69–78.
  5. Zhang X-W, Choe Y-H, Park Y-J, Kim B-S. Effect of Korean arbor vitae (Thuja koraiensis) extract on antimicrobial and antiviral activity. African J Pharm Phamacology. 2014;8(10):274–7.
  6. Lis A, Swaczyna A, Krajewska A, Mellor K. Chemical Composition of the Essential Oils From Twigs, Leaves, and Cones of Thuja plicata and Its Cultivar Varieties “Fastigiata”, “Kornik,” and “Zebrina.” Nat Prod Commun. 2019;14(7):1–5.
  7. https://threatenedconifers.rbge.org.uk/conifers/thuja-standishii. 2020;
  8. https://www.conifers.org/cu/Thuja_sutchuenensis.php. 2020.
  9. Abdallah EM, Elsharkawy ER. Antibacterial Activity of Ethyl Acetate Extract of Platycladus orientalis against Staphylococcus saprophyticus. J Pure Appl Microbiol. 2019;13(2):1063–8.
  10. https://www.conifers.org/cu/Platycladus.php. 2020.
  11. Hassanzadeh MK, Rahimizadeh M, Bazzaz BSF, Emami SA, Assili J. Chemical and Antimicrobial Studies of Platycladus orientalis Essential Oils. Pharm Biol. 2001;39:388–90.
  12. Amri I, Hanana M, Jamoussi B, Hamrouni L, Ismail A, Mohsen H, et al. Chemical composition of Thuja orientalis L. essential oils and study of their allelopathic potential on germination and seedling growth of weeds. Arch Phytopathol Plant Prot. 2015;48(1):18–27.
  13. Schmelzer GH, Gurib-Fakim A. Plants resources of Tropical Africa 11(1); Medicinal Plants 1. Wageningen, Netherlands: PROTA Foundation/Backhuys Publishers/CTA; 2008.
  14. An A, Sunanda M, Shubhangi B, Jain A. investigation on bark of Thuja Orientalis Linn ( Cupressaceae ). 2016;5(5):111–3.
  15. Dash AK, Mishra J. Chemopreventive potential of Platycladus orientalis extract against liver oxidative injury in experimentally challenged rats. In: 2nd International Conference and Exhibition on Pharmacognosy, Phytochemistry & Natural Products. 2014.
  16. Shan M-Q, Shang J, Ding A-W. Platycladus orientalis leaves: A systemic review on botany, phytochemistry and pharmacology. Am J Chin Med. 2014;42(3):523–42.
  17. Srivastava P, Kumar P, K. Singh D, K. Singh V. Biological Properties of Thuja Orientalis Linn. Adv Life Sci. 2012;2(2):17–20.
  18. http://database.prota.org/PROTAhtml/Platycladus%20orientalis_En.htm. 2019.
  19. Akkol AK, Ilhan M, Demirel MA, Keles H, Tumen I, Suntar I. Thuja occidentalis in a rat model of polycystic ovary syndrome Citation metadata. J Ethnopharmacol. 2015;168:25–30.
  20. Patil SS, Mahajan UB, Goyal SN, Belemkar S, Patil CR. Homoeopathic drug dilutions of Thuja occidentalis attenuate complete Freund’s adjuvant‑induced arthritis in Wistar rats. Indian J Res Homoeopath. 2018;12(4):202–11.
  21. Biswas R, Mandal SK, Dutta S, Bhattacharyya SS, Boujedaini N, Khuda-Bukhsh AR. Thujone-Rich Fraction of Thuja occidentalis Demonstrates Major Anti-Cancer Potentials: Evidences from In Vitro Studies on A375 Cells. Evidence-Based Complement Altern Med. 2011;2011:1–16.
  22. Hou L, Cui Y, Li X, Chen W, Zhang Z, Pang X, et al. Genetic Evaluation of Natural Populations of the Endangered Conifer Thuja koraiensis Using Microsatellite Markers by Restriction-Associated DNA Sequencing. Genes (Basel). 2018;9(4):1–16.
  23. Moerman D. Native American Ethnobotany. Portland- Oregon: Timber Press; 1998.
  24. Han X., Parker TL. Arborvitae (Thuja plicata) essential oil significantly inhibited critical inflammation- and tissue remodeling-related proteins and genes in human dermal fibroblasts. Biochim Open. 2017;4:56–60.
  25. https://www.conifers.org/cu/Thuja_standishii.php. 2020.
  26. Jian W. Thuja sutchuenensis wood medicinal pillow for treating cervical spondylosis. 2016. p. 1–5.
  27. Shin I ‑S., Shin N ‑R., Jeon C ‑M., Kwon O-K, Hong J ‑M., Kim H ‑S., et al. Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma. Mol Med Rep. 2015;12:4640–6.
  28. Yang HJ, Kim MJ, Kang S, Moon NR, Kim DS, Lee NR, et al. Topical Treatments of Saussurea Costus Root and Thuja Orientalis L. Synergistically Alleviate Atopic Dermatitis-Like Skin Lesions by Inhibiting Protease-Activated receptor-2 and NF-κB Signaling in HaCaT Cells and Nc/Nga Mice. J Ethnopharmacol. 2017;199:97–105.
  29. Chakraborty S, Afaq N, Singh N, Majumdar S. Antimicrobial activity of Cannabis sativa, Thuja orientalis and Psidium guajava leaf extracts against methicillin-resistant Staphylococcus aureus. J Integr Med. 2018;16:350–7.
  30. Mateen H, Tariq SA, Habib SH, Khizar SH, Popalza A. J, Hussain A. Antimicrobialactivity of Thuja orientalis in combination with Ciprofloxacin against Pseudomonas aeruginosa. J Khyber Med Univ. 2019;11(2):90–7.
  31. Seo K-S, Lee B, Yun KW. Chemical Composition and Antibacterial Activity of Essential Oils Extracted from Wild and Planted Thuja orientalis Leaves in Korea. J Essent Oil Bear Plants. 2019;22(5):1407–15.
  32. Mohammed BJ. Study the inhibitory effect of Thuja occidentalis against Pseudomonas aeruginosa isolated from surgical wounds in vitro and in vivo. Int J Sci Nat. 2017;8(2):352–7.
  33. Eltayeb IM, Hamid AS. Phytochemical screening and antimicrobial activity OF Thuja occidentalis seeds extracts against the isolated common skin infecting microorganisms. Int J Pharm Pharm Sci. 2017;9(10):131–4.
  34. Brijesh K, Ruchi R, Sanjita D, Saumya D. Phytoconstituents and Therapeutic potential of Thuja occidentalis. Res J Pharm Biol Chem Sci. 2012;3(2):354–62.
  35. Osadebe PO, Uzor EU, Uzor PF. Natural Products as Potential Sources of Antidiabetic Drugs. Br J Pharm Res. 2014;4(17):2075–95.
  36. Pradhan P, Sarangdevot YS. Evaluation of antidiabetic activity of aerial parts of Thuja occidentalis. Plant Arch. 2020;20:957–62.
  37. Elsharkawy ER, Aljohar H, Abdel Raheim DM. Comparative Study of Antioxidant and Anticancer Activity of Thuja orientalis Growing in Egypt and Saudi Arabia. Br J Pharm Res. 2017;15:1–9.
  38. Islam S, Rahi S, Jerin I, Hasan KE, Ahmed SS, Ferdaus K, et al. Anti-proliferative activity of Thuja occidentalis seed extract through regulation of BAX and BCL-X gene exprssion. Int J Biosci. 2017;11(4):372–86.
  39. Dash A, Mishra J, Dash D. Phytochemical Investigation and Pharmacological Screening of Platycladus orientalis. Int J Pharm Sci Heal Care. 2014;1(4):94–102.
  40. Andhale PV, Jadhav RS, Bhalke RD, Tambe VD, Kolhe MH. Analgesic Activity of Thuja orientalis Leaves. Res J Pharm Tech. 2010;3:135–437.
  41. Janadri S, Gowda YHS. Evaluation of analgesic and anti-inflammatory activity of Thuja occidentalis leaves in chemically induced animal models. Adv Pharm J. 2016;1(1):26–30.
  42. Zhang N, Park DK, Park HJ. Hair growth-promoting activity of hot water extract of Thuja orientalis. BMC Complement Altern Med. 2013;13(9):1–11.
  43. Jasuja ND, Sharma S, Choudhary J, Joshi SC. Essential Oil and Important Activities of Thuja orientalis and Thuja occidentalis. J Essent Oil Bear Plants. 2015;18:931–49.
  44. Stan MS, Voicu SN, Caruntu S, Nica IC, Olah N-K, Burtescu R, et al. Antioxidant and Anti-Inflammatory Properties of a Thuja occidentalis Mother Tincture for the Treatment of Ulcerative Colitis. Antioxidants. 2019;8:1–19.
  45. Jasuja ND, Sharma SK, Saxena R, Choudhary J, Sharma R, Joshi SC. Antibacterial, antioxidant and phytochemical investigation of Thuja orientalis leaves. J Med Plants Res. 2013;7:1886–93.
  46. Selim Y, El-Sharkawy E, Abd El-Azim M. M. New cytotoxic flavonoids from aerial parts of Platycladus orientalis L. Nat Prod Res. 2020;34(12):1–9.
  47. Venugopala KN, Rashmi V, Odhav B. Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity. Biomed Res Int. 2013;2013:1–14.
  48. Kozioł A, Stryjewska A, Librowski T, Sałat K, Gaweł M, Moniczewski A, et al. An Overview of the Pharmacological Properties and Potential Applications of Natural Monoterpenes. Mini-Reviews Med Chem. 2014;14:1156–68.
  49. Darwish RS, Hammoda HM, Ghareeb DA, Abdelhamid ASA, El Naggar EB, Harraz FM, et al. Efficacy-directed discrimination of the essential oils of three Juniperus species based on their in-vitro antimicrobial and anti-inflammatory activities. Ethnopharmacology. 2020;259:1–12.
  50. https://www.ema.europa.eu/en/documents/public-statement/draft-public-statement-use-herbal-medicinal-products-containing-thujone_en.pdf. 2011.
  51. Halicioglu O, Astarcioglu G, Yaprak I, Aydinlioglu H. Toxicity of Salvia officinalis in a Newborn and a Child: An Alarming Report. Pediatr Neurol. 2011;45(4):259–60.
  52. Da Silveira e SR d. C, Andrade LN, de Sousa DP. Sesquiterpenes from Essential Oils and Anti-Inflammatory Activity. Nat Prod Commun. 2015;10:1767–74.
  53. Kim CS, Suh WS, Choi SU, Kim KH, Lee KR. Two New Diterpenoids from Thuja orientalis and Their Cytotoxicity. Bull Korean Chem Soc. 2014;35:2855–8.
  54. Kim CS, Choi SU, Lee KR. Three New Diterpenoids from the Leaves of Thuja orientalis. Planta Med. 2012;78:485–7.
  55. Iwamoto M, Ohtsu H, Tokuda H, Nishino H, Matsunagaa S, Tanakaa R. Anti-tumor Promoting Diterpenes from the Stem Bark of Thuja standishii (Cupressaceae). Bioorg Med Chem. 2001;9:1911–21.
  56. Iwamoto M, Minami T, Tokuda H, Ohtsu H, Tanaka R. Potential antitumor promoting diterpenoids from the stem bark of Thuja standishii_ __. Planta Med. 2003;69(1):69–72.
  57. Yan L, He X, Jin Y, Wang J, Liang F, Pei R, et al. Modulation of the Aβ-Peptide-Aggregation Pathway by Active Compounds From Platycladus orientalis Seed Extract in Alzheimer’s Disease Models. Front Aging Neurosci. 2020;12:1–11.
  58. Suzuki S, Umezawa T. Biosynthesis of lignans and norlignans. J Wood Sci. 2007;53:273–84.
  59. Teponno RB, Kusari S, Spiteller M. Recent advances in research on lignans and neolignans. Nat Prod Rep. 2016;33:1044–92.
  60. Cunha WR, Silva MLA., Veneziani RCS, A. SR, Bastos JK. Lignans: Chemical and Biological Properties. In: Rao V, editor. Phytochemicals A Global Perspective of Their Role in Nutrition and Health. Intech; 2012.
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