Assessment of the Prognostic Role of Platelets-Lymphocytes and Neutrophil- Monocyte Ratios in Chronic Lymphocytic Leukemia | ||
| SECI Oncology Journal | ||
| Volume 12, Issue 1, January 2024, Pages 39-46 | ||
| Abstract | ||
| Background: The most prevalent form of leukemia in the western world is chronic lymphocytic leukemia (CLL). Today, there is a lot of worry over the evaluation of the platelets-lymphocytes and neutrophil-monocyte ratios in CLL. Aim of work: To assess platelet –lymphocyte ratio (PLR), neutrophil- monocyte ratio (NMR), neutrophil –lymphocyte ratio (NLR) and lymphocyte –monocyte ratio (LMR) as biomarkers for CLL prognosis and to evaluate the correlation of theses parameters with other established prognostic factors as CD38 and ZAP70 and their correlation with survival outcome of patients with CLL. Methods: This retrospective study was conducted at medical oncology and clinical pathology departments at south Egypt cancer institute during the period from 2010 to 2020. A total of 142 consecutive CLL patients who admitted to SECI. Of these, only 90 CLL patients had full data, so they were enrolled in the current study. We collected patients’ data at diagnosis and after finishing treatment (after three months). The collected data include laboratory data (Complete blood picture, liver function, kidney function, Lactate dehydrogenase and immunophenotyping), clinical data (history and complete clinical examination), imaging data (abdominal ultrasound and Compturized tomography) and outcome data. Results: Regarding immunophenotyping all patients showed co-expression of CD5, CD19 and CD23. Also, CD200 was expressed in 94.9% of CLL patients, ZAP70 was expressed in 33.3% of CLL patients, CD38 was expressed in 60.7%, 35.4% of CLL patients had Kappa light chain restriction while 60.4% had Lambda light chain restriction. The studied CLL cases have significantly lower PLR, NMR, and NLR levels and higher LMR level than that of matched controls. After three months of treatment, PLR, NMR, and NLR biomarkers levels were significantly increased and LMR was decreased. Conclusion: At the time of diagnosis, patients with CLL have abnormal haematological biomarkers (PLR, NMR, NLR, and LMR), which are normalized by treatment. In CLL patients, increased PLR, NMR, and NLR play a positive predictive impact. | ||
| Keywords | ||
| Chronic lymphocytic leukemia; Platelet lymphocyte ratio; Neutrophil monocyte ratio | ||
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