High Environmental Temperature Induces Oxidative Stress, Reduced Sow Productivity and Increased Piglet Mortality

ABIOLA, J. O., OMOTOSHO, O. O., and IGADO, O. O., 2017. Meningoencephalocele, bilateral anorchia with radial and fibular hemimelia in a piglet. Journal of Morphological Science, 34 (3) p. 152-155. https://doi.org/10.4322/jms.107716

ABDEL-AZIZ, H. O., HAMDAN, H. M., and RAGAB, E. E., 2018. The histological effects of zinc oxide nanoparticles on the kidney of adult male rabbits. Sohag Medical Journal, 22(2), 297-301. https://doi.org/10.21608/smj.2018.40959

AHMED, M. O., OGEDENGBE, K., and LAWAL, N. S., 2022. Innovative Trend Analysis of Hydro-Meteorological variables in Ibadan, Nigeria. Journal of Fundamental and Applied Sciences. 14(1), 288-311. doi: http://dx.doi.org/10.4314/jfas.v14i1.15

AJAYI, A. E., and OLUFAYO, A. A., 1998. The sequence of wetanddrydays at Ibadan and Onne (sub-humid zone of Nigeria). Nigerian journal of technology 21(1):38-44

AO, X., and KIM, I.H., 2020. Effects of grape seed extract on performance, immunity, antioxidant capacity, and meat quality in Pekin ducks. Poultry Science 99, 2078–2086. https://doi.org/10.1016/j.psj.2019.12.014

ADEBIYI, O. A., MUIBI, M. A., and ALABA, O., 2017. Performance and behavioural characteristics of Pigs as affected by types and duration of evaporative cooling. Nigerian Journal of Animal Science 2017 (2):103 – 113

BING XIA, WEIDA WU, WEI FANG, XIAOBIN WEN, JINGJING XIE, and HONGFU ZHANG, 2022. Heat stress-induced mucosal barrier dysfunction is potentially associated with gut microbiota dysbiosis in pigs, Animal Nutrition 8. Pp. 289-299, https://doi.org/10.1016/j.aninu.2021.05.012.

BROWN-BRANDL, T. M., R. A. EIGENBERG, J. A. NIENABER, and S. D. KACHMAN. 2001. Thermoregulatory profile of a newer genetic line of pigs. Livestock Production Science 71: 253-260. https://doi.org/10.1016/S0301-6226(01)00184-1

BUHIMSCHI, I. A., SAADE, G. R. CHWALISZ, K., and GARFIELD, R. E., 1998. The nitric oxide pathway in preeclampsia: pathophysiological implications. Human Reproduction Update 4: 25-42. https://doi.org/10.1093/humupd/4.1.25

CELI, P. 2011. Biomarkers of oxidative stress in ruminant medicine. Immunopharmacology and Immunotoxicology 33: 233-240. https://doi.org/10.3109/08923973.2010.514917

CHAUDHARY, S. S., SINGH, V. K., UPADHYAY, R. C., PURI, G., ODEDARA, A. B., and PATEL, P. A., 2015. Evaluation of physiological and biochemical responses in different seasons in Surti buffaloes. Veterinary World 8, 727–731. https://doi.org/10.14202/vetworld.2015.727-731

CUI, Y., HAO, Y., LI J., BAO, W., LI, G., GAO, Y., and GU, X., 2016. Chronic Heat Stress Induces Immune Response, Oxidative Stress Response, and Apoptosis of Finishing Pig Liver: A Proteomic Approach. International Journal of Molecular Sciences 17(5) :393. https://doi.org/10.3390/ijms17050393.

CUTLER, R. S., FAHY, V. A., CRONIN, G. M., and SPICER, E. M., 2006. Preweaning mortality. In BE Straw, JJ Zimmerman, S D’Alliare, DJ Taylor, eds. Diseases of Swine, 9th ed. Ames, IA: Blackwell Publishing, pp. 1005–1006.

D’ALLAIRE, S., DROLET, R., and BRODEUR, D., 1996. Sow mortality associated with high ambient temperatures. The Canadian Veterinary Journal 37, 237–239. PMID: 8801022, PMCID: PMC1576357

EGBINOLA, C. N., and AMOBICHUKWU A. C., 2013. Climate Variation Assessment Based on Rainfall and Temperature in Ibadan, South-Western, Nigeria. Journal of Environment and Earth Science. Vol. 3, No.11

ELLMAN, G. L. 1959. Tissue sulfhydryl groups. Arch Biochem Biophys 82(1):70–77. https://doi.org/10.1016/0003-9861(59)90090-6

GODYŃ, D., HERBUT, P., ANGRECKA, S., and CORRÊA VIEIRA, F. M., 2020 Use of differentcooling methods in pig facilities to alleviate the effects of heatstress—a review. Animals. 10(9):1459. https://doi.org/10.3390/ani10091459

GONYOU, H.W., LERMAY, S.P., and ZHANG, Y., 2006. Effects of the environment on productivity and disease. In BE Straw, JJ Zimmerman, S D’Allaire, DJ Taylor, eds. Diseases of Swine, 9th ed. Ames, IA: Blackwell Publishing, pp. 1027–1038.

GUPTA, M., KUMAR, S., DANGI, S. S., and JANGIR, B. L., 2013. Physiological, biochemical and molecular responses to thermal stress in goats. International Journal of Livestock Research 3, 27–38. https://doi.org/10.5455/ijlr.20130502081121

HABIG, W. H., PABST, M. J., and JACOBY, W. B., 1974. Glutathione-S-transferase activity: The first enzymatic step in Mercapturic Acid formation. Journal of Biological Chemistry, 249, 7130–7139. PMID: 4436300

HASSAN, F. A., MAHROSE, K.M., and BASYONY, M.M.,  2016. Effects of grape seed extract as a natural antioxidant on growth performance, carcass characteristics and antioxidant status of rabbits during heat stress. Archives of Animal Nutrition 70 (2), 141–154. https://doi.org/10.1080/1745039x.2016.1139609.

HOSSEINI-VASHANA, S. J., SAFDARI-ROSTAMABADA, M., PIRAYB, A. H., and SARIR, H., 2019. The growth performance, plasma biochemistry indices, immune system, antioxidant status, and intestinal morphology of heat stressed broiler chickens fed grape (Vitis vinifera) pomace. Animal Feed Science and Technology 259, 114343. https://doi.org/10.1016/j.anifeedsci.2019.114343

HUYNH, T. T. T., and AARNINK, A. J. A., 2005. Heat stress in growing pigs. available at https://research.wur.nl/en/publications/heat-stress-in-growing-pigs. Accessed on 14 December, 2023.

HUYNH, T. T. T., AARNINK, A. J. A., TRUONG, C. T., KEMP B., and VERSTEGEN, M. W. A., 2006: Effects of tropical climate and water-cooling methods on growing pigs’ responses. Livestock Science, 104(3): 278-291. https://doi.org/10.1016/j.livsci.2006.04.029

IGBOKWE, I. O., and MADUKA, C. V., 2018. Disease burden affecting pig production in Nigeria: Review of current issues and challenges. Revue D'élevage et de Médecine Vétérinaire Des Pays Tropicaux. 71 (1-2): 87-95 https://doi.org/10.19182/remvt.31290

JOHNSON, J. S., and BAUMGARD, L. H., 2019. PHYSIOLOGY SYMPOSIUM: Postnatal consequences of in utero heat stress in pigs. Journal of Animal Science 97(2):962-971. https://doi.org/10.1093/jas/sky472.

JOLLOW, D. J., MITCHELL, J. R., and ZAMPAGLIONE, N., 1974. Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3, 4- bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 11(3): 151–169. https://doi.org/10.1159/000136485 32.

KLEM, T. B., BLEKEN, E., MORBERG, H., THORESEN, S. I., and FRAMSTAD, T., 2010. Hematologic and biochemical reference intervals for Norwegian crossbreed grower pigs. Veterinary Clinical Pathology 39:221–226. https://doi.org/10.1111/j.1939-165X.2009.00199.x.

LACETERA N 2019. Impact of climate change on animal health and welfare. Animal Frontiers 9, 26–31. https://doi.org/10.1093/af/vfy030

LARSON-MEYER, D. E., INGOLD, B. C., FENSTERSEIFER, S. R., AUSTIN, K. J., WECHSLER, P. J., HOLLIS, B. W., MAKOWSKI, A. J., and ALEXANDER, B.M., 2017 Sun exposure in pigs increases the vitamin D nutritional quality of pork. PLoS One. 12(11):e0187877. https://doi.org/10.1371/journal.pone.0187877.

LU, T., HARPER A., ZHAO J., ESTIENNE M., and DALLOUL R., 2014. Supplementing antioxidants to pigs fed diets high in oxidants: I. Effects on growth performance, liver function, and oxidative status. Journal of animal science 92: 5455-5463. https://doi.org/10.2527/jas.2013-7109

MAYORGA, E. J.; DAVID, R., RAMIREZ, B. C., ROSS J. W. and BAUMGARD, L. H. Heat stress adaptations in pigs. Animal Frontiers. v. 9. No. 1. p. 54–61. 2019. https://doi.org/10.1093/af/vfy035

MISRA H. P. and FRIDOVICH I. 1972. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. Journal of Biological Chemistry 247(10):3170–3175. https://doi.org/10.1016/S0021-9258(19)45228- 9

MSDVetmanual 2023, Serum Biochemical Analysis Reference Ranges available at https://www.msdvetmanual.com/multimedia/table/serum-biochemical-analysis-reference-range. Accessed on November 29, 2023.

MU, C., HAO, X., ZHANG, X., ZHAO, J. and ZHANG, J. 2021. Effects of high-concentrate diet supplemented with grape seed procyanidins on the colonic fermentation, colonic morphology, and inflammatory response in lambs. Animal Feed Science and Technology. 281, 115118 https://doi.org/10.1016/j.anifeedsci.2021.115118.

MUTUA J. Y., MARSHALL K., PAUL B. K. and NOTENBAERT A. M. O. 2020. A methodology for mapping current and future heat stress risk in pigs. Animal, 14(9). https://doi.org/10.1017/S1751731120000865.

NAZIFI S., SAEB M., ROWGHANI E. and KAVEH K. 2003. The influences of thermal stress on serum biochemical parameters of Iranian fat-tailed sheep and their correlation with triiodothyronine (T3), thyroxine (T4) and cortisol concentrations. Comparative Clinical Pathology 12, 135–139. https://doi.org/10.1007/s00580-003-0487-x

NOAA: National Oceanic and Atmospheric Administration. 1976. Livestock Hot Weather Stress. Operations Manual Letter c-31- 76. Kansas City.

OGUNDIJO O. A., OMOTOSHO O. O., AL-MUSTAPHA A. I., ABIOLA J. O.  AWOSANYA E. J., ODUKOYA A, OWOICHO S., OYEWO M., IBRAHIM A. ORUM T. G., NANVEN M. B., BOLAJOKO M. B., LUKA P. and ADEYEMO O. K. 2023. A multi-state survey of farm-level preparedness towards African swine fever outbreak in Nigeria, Acta Tropica, 246. https://doi.org/10.1016/j.actatropica.2023.106989

OKORUWA M. I 2014. Effect of heat stress on thermoregulatory, live bodyweight and physiological responses of dwarf goats in southern Nigeria. European Science Journal 10, 255–264. Corpus ID: 261543298

OLALEYE, S. B., ADARAMOYE, O. A., ERIGBALI, P. P., and ADENIYI, O. S., 2007. Lead exposure increases oxidative stress in the gastric mucosa of HCl/ ethanol-exposed rats. World Journal of Gastroenterology, 13, 5121–5126.  https://doi.org/10.3748/wjg.v13.i38.5121.

OMOTOSHO O.O, EMIKPE B.O., LASISI O. T and OLADUNJOYE V. O. 2016. Pig Slaughtering in Southwestern Nigeria: Peculiarities, Animal Welfare Concerns and Public Health Implications. African Journal of Infectious Diseases. 10(2): 146 – 155. https://doi.org/10.21010/ajid.v10i2.11

OYAGBEMI, A. A., OMOBOWALE, T. O., AKINRINDE, A. S., SABA, A. B., OGUNPOLU, B. S., and DARAMOLA, O., 2015. Lack of reversal of oxidative damage in renal tissues of lead acetate-treated rats. Environmental Toxicology, 30, 1235–1243. https://doi.org/10.1002/tox.21994

PATRA, A.K. and KAR, I., 2021. Heat stress on microbiota composition, barrier integrity, and nutrient transport in gut, production performance, and its amelioration in farm animals, 63 (2), 211–247. https://doi.org/10.5187/jast.2021.e48.

PHS (Public Health Service) (2015). Public health service policy on humane care and the use of laboratory animals. Washington, DC: US Department of Health and Human Services. Available at https://olaw.nih.gov/policies-laws/phs-policy.htm accessed 10 December 2022

POLLMANN, D. S. 2010. Seasonal effects on sow herds: industry experience and management strategies. Journal of Animal Science 88 (Suppl. 3):9 (Abstr) available at https://www.asas.org/docs/midwest/2010mwabstract.pdf?sfvrsn=5372c05e_2

PRAGNA, P., SEJIAN, V., SOREN, N.M., BAGATH, M., KRISHNAN, G., BEENA, V., DEVI, P.I.,  and BHATTA, R., 2018. Summer season induced rhythmic alterations in metabolic activities to adapt to heat stress in three indigenous (Osmanabadi, Malabari and Salem Black) goat breeds. Biological Rhythm Research 49, 551–565. https://doi.org/10.1080/09291016.2017.1386891

RANA, M. S., HASHEM, M. A., SAKIB, M. N., and KUMAR, A., 2014. Effect of heat stress on blood parameters in indigenous sheep. Journal of Bangladesh Agriculture 12, 91–94. https://doi.org/10.3329/jbau.v12i1.21253

RENAUDEAU, D., A. COLLIN, S. YAHAV, V. DE BASILIO, GOURDINE, J. L., and COLLIER, R. J., 2012. Adaptation to hot climate and strategies to alleviate heat stress in livestock production. Animal 6:707–728. https://doi.org/10.1017/s1751731111002448

RAUW, W. M., MAYORGA, E. J., LEI, S. M., DEKKERS, J. C. M., PATIENCE, J. F., GABLER, N. K., LONERGAN, S. M., and BAUMGARD, L H., 2017. Effects of Diet and Genetics on Growth Performance of Pigs in Response to Repeated Exposure to Heat Stress. Front. Genet. 8:155. https://doi.org/10.3389/fgene.2017.00155

ROJAS-DOWNING, M. M., NEJADHASHEMI, A. P., HARRIGAN, T., and WOZNICKI, S. A., 2017. Climate change and livestock: impacts, adaptation, and mitigation. Climate Risk Management 16, 145–163. https://doi.org/10.1016/j.crm.2017.02.001

ROTRUCK, J. T,, POPE, A. L., GANTHER, H. E., SWANSON, A. B., HAFEMAN, D. G., and HOEKSTRA, W. G., 1973 Selenium: biochemical role as a component of glutathione peroxidase. Science 179: 588e90. https://doi.org/10.1126/science.179.4073.588

SEJIAN, V., BHATTA, R., GAUGHAN, J.B., DUNSHEA, F.R., and LACETERA, N., 2018. Review: Adaptation of animals to heat stress, Animal, Volume 12, Supplement 2, Pages s431-s444, ISSN 1751-7311, https://doi.org/10.1017/S1751731118001945.

SHILJA, S., SEJIAN V., BAGATH, M., MECH, A., DAVID, C. G., KURIEN, E. K., VARMA, G., and BHATTA, R., 2016. Adaptive capability as indicated by behavioural and physiological responses, plasma HSP70 level, and PBMC HSP70 mRNA expression in Osmanabadi goats subjected to combined (heat and nutritional) stressors. International Journal of Biometeorology 60, 1311–1323. https://doi.org/10.1007/s00484-015-1124-5

SIRINI, A.M., and AMARAKOON, B. K., 2017. Regulation of oxidative stress in weaned piglets challenged with Escherichia coli. A Thesis submitted to Faculty of Graduate studies of The University of Manitoba. Available at https://mspace.lib.umanitoba.ca/items/52199d05-9e68-4d0f-9a77-dda5f1627475. Accessed December 1, 2023

STENDER, D. R., HARMON, J. D., WEISS, J. D., and COX, D., 2003. Comparison of different styles of swine finishing facilities within a uniform production system. Appl. Eng. Agric. 19, 79–82. https://doi.org/10.13031/2013.12734

TANG, L. P., LIU, Y. L., ZHANG, J. X., DING, K. N., LU, M. H., and HE, Y.M., 2022. Heat stress in broilers of liver injury effects of heat stress on oxidative stress and autophagy in liver of broilers. Poultry Science 101(10). https://doi.org/10.1016/j.psj.2022.102085

TURNER, A. G., ANDERSON, P. H., and MORRIS, H. A., 2012. Vitamin D and bone health. Scandinavian Journal of Clinical and Laboratory Investigation 243: 65–72. https://doi.org/10.3109/00365513.2012.681963

UCHIIDE, I., IHARA, T., and SUGAMATA, M., 2002. Pathological evaluation of the rat endometriosis model. Fertility and sterility 78: 782-786. https://doi.org/10.1016/s0015-0282(02)03327-7.

URKMEZ, E., and BIRICIK, H., 2022. Grape seed extract supplementation in heat-stressed preweaning dairy calves: I. Effects on antioxidant status, inflammatory response, hematological and physiological parameters, Animal Feed Science and Technology, 292. https://doi.org/10.1016/j.anifeedsci.2022.115421.

VALKO, M., RHODES, C., MONCOL, J., IZAKOVIC, M., and MAZUR, M., 2006. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-biological interactions 160: 1-40. https://doi.org/10.1016/j.cbi.2005.12.009.

VARASTEH, S., BRABER, S., AKBARI, P., GARSSEN, J., and FINK-GREMMELS, J., 2015 Differences in susceptibility to heat stress along the chicken intestine and the protective effects of galacto-oligosaccharides. PLOS ONE. 10:e0138975. https://doi.org/10.1371/journal.pone.0138975.

VARSHNEY, R., and KALE, R. K., 1990. Effect of calmodulin antagonists on radiation induced lipid peroxidation in microsomes. International Journal of Biological Macromolecules 158: 733-441. https://doi.org/10.1080/09553009014552121

WOLFF S. F. 1994 Ferrous ion oxidation in the presence of ferric ion indicator xylenol orange for measurement of hydrogen peroxides. Methods Enzymol 233(2):182–189. https://doi.org/10.1016/0003-2697(92)90122-n

VERMEER, H. M., and  AARNINK A. J. A., 2023. Review on heat stress in pigs on farm. EU Reference Centre for Animal Welfare (Pigs). Wageningen Livestock Research, The Netherlands. Available at https://edepot.wur.nl/587090  Accessed on January 18, 2023.

ZHAO, W, ARTAIZ, O. IQBAL, Y., LE, H.H., DIGIACOMO, K, LEURY, B.J., FOTHERGILL, L.J., FURNESS, J.B., LIU, F., GREEN, M.P., FINGER, B.J., NAVARRO, M., ROURA, E., D'SOUZA, D.N., DUNSHEA, F.R., PLUSH, K.J., and COTTRELL, J.J., 2022. Heat stress of gilts around farrowing causes oxygen insufficiency in the umbilical cord and reduces piglet survival, animal, 16 (11). https://doi.org/10.1016/j.animal.2022.100668.

ZHONG, R. Z., and ZHOU, D.W., 2013. Oxidative stress and role of natural plant derived antioxidants in animal reproduction. Journal of Integrative Agriculture 12: 1826-1838. https://doi.org/10.1016/S2095-3119(13)60412-8

ZULOVICH, J. M. 2012. Effect of the Environment on Health. In Diseases of Swine, Tenth Edition. Edited by Jeffrey J. Zimmerman, Locke A. Karriker, Alejandro Ramirez, Kent J. Schwartz, Gregory W. Stevenson. pp 60-66. John Wiley & Sons, Inc. Published 2012 by John Wiley & Sons, Inc.