ADIPOCYTES FATTY ACID BINDING PROTEIN AND ITS RELATION TO SUBCLNICAL ATHEROSCLEROSIS IN SUBJECTS WITH TYPE 2 DIABETES | ||
| ALEXMED ePosters | ||
| Article 1, Volume 6, Issue 1, January 2024, Pages 25-26 | ||
| Document Type: Preliminary preprint short reports of original research | ||
| DOI: 10.21608/alexpo.2024.268502.1782 | ||
| Authors | ||
| Magui Abd Elmonem Shalash1; Noha Said Kandil2; Reem Fathalla3; Omnia Ezz Eldin Fathy Alsaadany4; Aya Fathy Radwan* 1 | ||
| 1Department of Internal Medicine, Faculty of Medicine, University of Alexandria | ||
| 2Department of Hematology, Medical Research Institute, Alexandria University | ||
| 3Department of Internal Medicine, Faculty of Medicine, Alexandria University | ||
| 4Department of Radiodiagnosi, Faculty of Medicine, University of Alexandria | ||
| Abstract | ||
| Diabetes mellitus (DM) is the most common endocrine disorderwhichcharacterized by high blood sugar levels over prolonged periods. Although the precise mechanisms through which diabetes increases the likelihood of atherosclerotic plaque formation are not completely defined, the association between the two is profound. Atherosclerotic cardiovascular disease (ASCVD) remains the principal cause of death and disability among patients with diabetes mellitus, especially in those with type 2 diabetes mellitus in whom it typically occurs 14.6 years earlier, with greater severity, and with more diffuse distribution than in individuals without diabetes mellitus. Furthermore, about two-thirds of deaths in people with diabetes mellitus are attributable to cardiovascular disease: of these, ≈40% are from ischemic heart disease, 15% from other forms of heart disease, principally congestive heart failure, and ≈10% from stroke. Intensive treatment of multiple cardiovascular risk factors can have a major impact among patients with diabetes. Reduction in glycosylated hemoglobin values, systolic and diastolic blood pressure, fasting serum cholesterol and triglyceride levels, and urinary albumin excretion rate all have their value in reducing cardiovascular morbidity and mortality. Adipocytes produce and secrete a variety of bioactive peptides, termed adipokines, which influence body weight, insulin sensitivity, lipid metabolism and vascular function. Adipocyte fatty acid binding protein (AFABP), also known as fatty acid binding protein-4 and aP2, has recently been suggested as a third adipokine, in addition to leptin and adiponectin, that is preferentially produced in and released from adipocytes. | ||
| Keywords | ||
| Diabetes mellitus (DM); SUBCLNICAL ATHEROSCLEROSIS; ADIPOCYTES FATTY ACID BINDING PROTEIN | ||
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