Magnetic Resonance Imaging Evaluation of Myocardial and Hepatic Iron Overload in Beta-Thalassaemia | ||
| Zagazig University Medical Journal | ||
| Article 28, Volume 30, Issue 8, November 2024, Pages 4564-4578 PDF (1.16 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2024.263788.3123 | ||
| Authors | ||
| Heba F. Tantawy1; Esraa Abdallah* 2; Khalid Shawky2; Marwa Elsayed Abd Elhamed3 | ||
| 1radiology department, Faculty of medicine | ||
| 2Radiology Department, Zagazig University, Egypt | ||
| 3Radiodiagnosis, faculty of Medicine, Zagazig University, Zagazig | ||
| Abstract | ||
| Background: Beta-Thalassemia major is an inherited condition characterized by a kind of anemia that causes the destruction of red blood cells, and a significant complication of this condition is the accumulation of excessive iron in body. Magnetic resonance imaging is the most commonly accessible modality that considered non-invasive for identifying or measuring the extent of iron buildup, as well as tracking the effectiveness of treatments that reduce iron levels. Methods: Prospective study involved 35 beta thalassemia thalassemia. 1.5 Tesla MRI machine was used to perform MRI scans of the liver and heart in all subjects in order to evaluate iron in the heart muscles or liver. Results: Serum ferritin among studied patients had a range from 300 up to 10000 ng /ml with a mean value of 3013.86 ± 3000.5 SD. There was no significant correlation between age or sex and hepatic or cardiac magnetic resonance imaging findings, but there was a significant negative correlation between ferritin levels with hepatic MRI T2 (P =0.037). Also, it was reported a statistical significant positive correlation between ferritin levels and R2 and LIC. It was noticed no significant correlation between ferritin levels assessed in the serum and cardiac MRI findings (P >0.05). As the grade of hepatic iron overload increase, ferritin levels increases. Conclusion: T2* MRI is currently the perfered tool for early detection, measurement, and monitoring of iron overload in the liver and heart. It is used to guide chelation therapy, which helps prevent iron-related heart problems and minimize patient mortality. | ||
| Keywords | ||
| Keywords: MRI; Beta-Thalassamia; Ferritin; Iron | ||
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