The Biochemical and Behavioral Alterations Induced by Experimental Hyperthyroidism in Male Rats | ||
| Suez Canal Veterinary Medical Journal. SCVMJ | ||
| Articles in Press, Accepted Manuscript, Available Online from 19 February 2024 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scvmj.2024.265936.1160 | ||
| Authors | ||
| Minnatullah Makadi* 1; Ibrahim Ashour Ibrahim2; Hoda Ibrahim Bahr2; Bassant Ahmed Elbaz3; Yasmina Kamal Mahmoud2 | ||
| 1Department of Biochemistry, Faculty of Veterinary Medicine, Arish University, North Sinai, Egypt. | ||
| 2Department of Biochemistry, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt. | ||
| 3Department of Hygiene, Zoonoses and Animal Behavior and Management, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt. | ||
| Abstract | ||
| Neurological and psychological disorders are the main complications specifically associated with hyperthyroidism conditions. The current study attempted to evaluate hyperthyroidism-mediated neurological disorders, behavioral manifeastaions, and related oxidative stress scenarios in experimental male rats. Hyperthyroidism was induced by administering L-thyroxine sodium at a dosage of 240 μg/kg via gastric gavage for a duration of 20 days, once daily. A comparative analysis was conducted using a dosage of 10 mg/kg of the commonly used pharmaceutical drug "propylthiouracil" to assess its effects in relation to the hyperthyroid rats. A total of twenty-four adult male albino rats were selected and assigned to three groups using a random allocation method as follows; negative control, positive control and propylthiouracil groups. The findings indicated that the animal model of hyperthyroidism showed a notable rise in the levels of serum total T3, FT3, total T4, and FT3, alongside with a drop in serum TSH level. There was a significant alterations in the dopaminergic and cholinergic systems; Rats treated with L-thyroxine and propylthiouracil displayed significantly poorer performance in the Novel recognition memory task, demonstrating the occurrence of memory impairment in the hyperthyroidism state. | ||
| Keywords | ||
| Hyperthyroidism; Propylthiouracil; Acetylcholinesterase; Dopamine; Behavioral assessment | ||
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