Hassan, N., Nasr El Dien, E., Kishk, R., Azab, H., Othman, A., Abdelaziz, B., Aboelros, S. (2024). Role of Tumor Necrosis Factor Alpha Gene Polymorphism (TNFα -308 G/A) and Prediction of Diabetic Nephropathy. test, 33(2), 67-72. doi: 10.21608/ejmm.2024.345486
Nashwa R. Hassan; Eman F. Nasr El Dien; Rania M. Kishk; Hasnaa Azab; Alyaa E. Othman; Basma M. Abdelaziz; Sara A. Aboelros. "Role of Tumor Necrosis Factor Alpha Gene Polymorphism (TNFα -308 G/A) and Prediction of Diabetic Nephropathy". test, 33, 2, 2024, 67-72. doi: 10.21608/ejmm.2024.345486
Hassan, N., Nasr El Dien, E., Kishk, R., Azab, H., Othman, A., Abdelaziz, B., Aboelros, S. (2024). 'Role of Tumor Necrosis Factor Alpha Gene Polymorphism (TNFα -308 G/A) and Prediction of Diabetic Nephropathy', test, 33(2), pp. 67-72. doi: 10.21608/ejmm.2024.345486
Hassan, N., Nasr El Dien, E., Kishk, R., Azab, H., Othman, A., Abdelaziz, B., Aboelros, S. Role of Tumor Necrosis Factor Alpha Gene Polymorphism (TNFα -308 G/A) and Prediction of Diabetic Nephropathy. test, 2024; 33(2): 67-72. doi: 10.21608/ejmm.2024.345486

Role of Tumor Necrosis Factor Alpha Gene Polymorphism (TNFα -308 G/A) and Prediction of Diabetic Nephropathy

Egyptian Journal of Medical Microbiology
Volume 33, Issue 2, April 2024, Pages 67-72    PDF (457.19 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2024.345486
Authors
Nashwa R. Hassan1; Eman F. Nasr El Dien2; Rania M. Kishk3; Hasnaa Azab* 3; Alyaa E. Othman4; Basma M. Abdelaziz5; Sara A. Aboelros1
1Clinical and Chemical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
2Internal Medicine Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
3Microbiology and Immunology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
4Department of Infectious Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
5Family Medicine Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Abstract
Background: Diabetic nephropathy, a chronic kidney disease resulting from diabetes mellitus microvascular complications, is thought to be the primary cause of end-stage renal failure. Gene mutations affecting the TNF gene can impact the generation of tumor necrosis factor-α (TNF-α), which has been associated with worse clinical outcomes in patients with diabetic nephropathy who are in severe condition. Objective: The purpose of this study was to assess the relationship between diabetic nephropathy and TNFα -308 G/A gene polymorphism in individuals with diabetes. Methodology:  50 diabetic individuals were recruited in this case-control research and were split into two groups: 25 patients with nephropathy and 25 patients without nephropathy. As a typical control group, a third set of blood donors (n = 25) appeared to be in good condition. Patients' information was gathered through the use of an interview questionnaire. The test for gene polymorphism was PCR. The TNF α308 G/A gene's A allele has a positive, statistically significant correlation (P-value ~0.05) with DN. Results: The prevalence of DN among the study participants may be predicted by the presence of an A allele in the TNF α308 G/A gene with a statistically significant P-value (P-value < 0.05). The study participants' TNF α308 G/A gene patterns and albumin/creatinine ratio did not exhibit a statistically significant relationship. Conclusion: According to this study, having an A allele in the TNF α308 G/A gene may contribute to the pathophysiology of diabetic nephropathy and be a predictor of nephropathy in diabetic populations.
Keywords
TNF- α; type 2 diabetes; diabetic nephropathy; TNFα -308 G/A; Polymorphism
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