Retrospective study of pattern of recurrence of breast cancer after surgery and adjuvant therapy | ||
| Sohag Medical Journal | ||
| Article 8, Volume 22, Issue 2, July 2018, Pages 51-60 PDF (85.78 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/smj.2018.34691 | ||
| Authors | ||
| Mohmed Soliman Gaber; Emad El Din Nabil Hassan; Aya Mahmoud Ibraheem | ||
| Department of Clinical Oncology ,Faculty of Medicine,Sohag University. | ||
| Abstract | ||
| Aim of the work:investigate pattern of breast cancer recurrence and the affecting factors on early and late recurrence and identify factors affecting site specific recurrence. Patients and methods:A retrospective study of 141 patients presented to clinical oncology department ,sohag university hospital between January 2000 and December 2014 diagnosed with invasive breast cancer.All of them underwent surgery either modified radical mastectomy,simple mastectomy or breast conservative surgery then received adjuvant systemic therapyeitherchemotherapy,endocrine therapy or both.Adjuvant radiotherapy was given when indicated.This study was conducted by hand search in the files. Results:90%(n=127) of our patients develop recurrence in first 5 year with 64.5%(n=91) of total number of patient in first 3 year. Patients still have risk of recurrence even after 10 years after primary treatment as 2 patients develop recurrence after 10 years. Among 141 patients with recurrence, 116 patients (82.2%) and 32 (22.6%) were involved with distant and loco regional recurrence, respectively.The most prevalent distant metastasis was seen in bone with liver , lung and brain metastasis in descending manner. Multiple organ metastasis was detected in 36% of patients. In our study in early recurrence group 70% (n=89) had tumor size more than 2 cm ,88%(n=113) had positive axillary lymph node ,98%(n=125) had high tumor grade indicate that tumor size larger than 2 cm, axillary lymph node involvement ,high tumor grade tend to be important prognostic factors in early recurrence. The present study has demonstrated that there is no significant tumor or patient characteristic associated with the site-specific risks of metastasis. Conclusion:Most breast cancer recurrence occur during first 5 year with peakincidence in1and 2year.Tumor size larger than2cm, lymph node involvement and high tumor grade tend to be important prognostic factors in early recurrence before 5 year. The most common exclusive first site of metastasis was bone and the least common is the brain.The current clinical practice of screening for site specific metastatic disease based on concerning patient specific signs or symptoms is supported. | ||
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