Abouelella, A., Madkour, H., Abdelraheem, M. (2018). N-acetyl-L-Cysteine ameliorates oxidative stress and reproductive toxicity induced by nicotine in male rats. test, 22(3), 299-305. doi: 10.21608/smj.2018.34692
Azza Mahmoud Abouelella; Hala Ibrahim Madkour; Mahmoud Abdelraheem. "N-acetyl-L-Cysteine ameliorates oxidative stress and reproductive toxicity induced by nicotine in male rats". test, 22, 3, 2018, 299-305. doi: 10.21608/smj.2018.34692
Abouelella, A., Madkour, H., Abdelraheem, M. (2018). 'N-acetyl-L-Cysteine ameliorates oxidative stress and reproductive toxicity induced by nicotine in male rats', test, 22(3), pp. 299-305. doi: 10.21608/smj.2018.34692
Abouelella, A., Madkour, H., Abdelraheem, M. N-acetyl-L-Cysteine ameliorates oxidative stress and reproductive toxicity induced by nicotine in male rats. test, 2018; 22(3): 299-305. doi: 10.21608/smj.2018.34692

N-acetyl-L-Cysteine ameliorates oxidative stress and reproductive toxicity induced by nicotine in male rats

Sohag Medical Journal
Article 35, Volume 22, Issue 3, October 2018, Pages 299-305    PDF (96.49 K)
Document Type: Original Article
DOI: 10.21608/smj.2018.34692
Authors
Azza Mahmoud Abouelella1; Hala Ibrahim Madkour1; Mahmoud Abdelraheem2
1Department of Pharmacology, Faculty of medicine, Sohag University
2Department of Pharmacology, Faculty of medicine, Assiut University
Abstract
Background: The current study assessed the protective role of N-acetyl-L-Cysteine in alleviating the detrimental effect of nicotine on reproductive functions in male rats.
Methods: twenty four adult male albino rats were divided into four groups of six rats. Control group was treated orally with 0.5ml/kg normal saline, nicotine treated group received 1.0 mg/kg of nicotine i.p, N-acetyl-L-Cysteine treated group received 100 mg/kg and 200 mg/kg i.p for four weeks.
Results: Nicotine caused significant reduction in serum level of total antioxidant, testosterone and luteinizing hormone. It also caused a significant reduction in sperm count. There was impairment in testicular histology of rats treated with nicotine. N-acetyl-L-Cysteine improved the reduction in sperm count, hormone levels and testicular alterations observed in nicotine treated rats.
Conclusion: The study shows that nicotine exerts significant deleterious effects on male reproductive system and the concurrent administration of N-acetyl-L-Cysteine ameliorated these detrimental effects.
Keywords
Nicotine; N-acetyl-L-Cysteine; Sperm count; FSH; LH; Testosterone and Total antioxidant
Supplementary Files
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