Leptin and Angiogenesis | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 4, Volume 33, Issue 1, June 2013, Pages 53-60 PDF (213.51 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2013.34892 | ||
| Authors | ||
| Hoda Moghazy1; Aida Mahmoud2 | ||
| 1Physiology Department, Faculty of Medicine, Sohag University | ||
| 2Biochemistry Department Faculty of Medicine, Sohag University | ||
| Abstract | ||
| Leptin is a 16 KDa protein, consists of 167 amino acid residues. It has many functions including angiogenesis. Leptin either induces angiogenesis itself or influences the levels of other angiogenic factors. The aim of the present investigation was to study the effect of leptin on the levels of the angiogenic factors: vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP) enzyme activity in prepubertal female albino rats. Twenty prebubertal female albino rats were divided randomly into two groups; 1st group (group I); rats were injected intraperitoneally with saline alone and considered as control group. The 2nd group (group II); its rats were daily intraperitoneally injected with leptin (recombinant rat leptin (L5073), Sigma-Aldrich) in a dose of 3 μg/g. body weight in 100 μl saline for 10 days. Obtained results revealed that leptin increased significantly the serum levels of both VEGF levels and TP activity. In addition, there was a positive correlation between VEGF levels and TP activity. | ||
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