Detection of Epstein-Barr virus infections in Egyptian Nasopharyngeal Carcinoma patients | ||
| Egyptian Journal of Medical Microbiology | ||
| Volume 33, Issue 2, April 2024, Pages 147-153 PDF (384.81 K) | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2024.282807.1242 | ||
| Authors | ||
| Enas Faisal Youness* 1; Safaa M. EL-Ageery2; heba degla2; Asser Sharkawy3; Rasha El-Mahdy2 | ||
| 1Medical Microbiology and Immunology, Laboratory of Talkha General Hospital, Ministry of Health and Population, Mansoura, Egypt | ||
| 2Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Egypt | ||
| 3Otolaryngeolgy department, Faculty of Medicine, Mansoura University, Egypt | ||
| Abstract | ||
| Background: Epstein Barr Virus (EBV) is associated with at least 1% of global cancers including nasopharyngeal cancer (NPC). The EBV DNA importance in the prediction of NPC has received little attention in non-endemic areas. Objective of the current study was to investigate the frequency of EBV in NPC patients compared to control of healthy individuals, and to study the relationship between EBV infection and clinicopathological and demographic characteristics. Methodology: A Case control study was conducted at the Hospital of Mansoura University. Fresh biopsies were collected from NPC patients and healthy controls over 2-years period between 2021 and 2023. After previous DNA extraction, real-time polymerase chain reaction was performed for EBV detection. Results: The study included a total of 28 patient biopsies proven NPC and 32 control individuals. A significantly higher prevalence of EBV in patients as compared with controls. The presence of the EBV infection was determined in half of the NPC patients and 6.3% of the control group. There was none statistically significant association between the presence of EBV and the clinicopathological features. Conclusion: EBV is prevalent in the NPC cases compared with controls. Further studies with a larger sample size are required to determine the true burden of EBV-associated NPC in Egypt | ||
| Keywords | ||
| Epstein-Barr virus infections; Nasopharyngeal Carcinoma; Real-time RT-PCR | ||
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