Applications of Bioinformatics on Genomics and Proteomics Levels Highlighted in Brucella Pathogen | ||
| Journal of Current Veterinary Research | ||
| Volume 6, Issue 1, April 2024, Pages 1-15 PDF (741.2 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jcvr.2024.352697 | ||
| Authors | ||
| Alyaa Elrashedy; Mohamed Nayel* ; Akram Salama; Mohamed E. Hasan | ||
| Abstract | ||
| In a variety of industries, including biotechnology and medicine, bioinformatics is extremely important. It offers an extensive range of uses in the structural and sequencing analysis of biological data. Each application has distinct functions in data interpretation, as database search sequence and alignment are essential tools that are prerequisites for more advanced applications like modelling, epitope predictions, and molecular docking. Genome annotation is thought to be the key to decoding the meaningless sequence data and providing crucial details about the protein-coding genes and genomic characteristics. Additionally, comparative modelling, fold modelling, and ab initio modelling are the three main approaches to protein modelling, which is fundamental for various proteomics applications. Epitopes prediction for B cells and T cells using MHC I and MHCII is another significant use. This may aid in the development of novel vaccine candidates for the prevention and management of infectious illnesses. Software can virtually dock the created 3D model or predicted epitopes with ligand to construct a new medicine or vaccination quickly and affordably. Using bioinformatics tools in diagnosis and control of brucellosis has a promising vision to eliminate the disease. | ||
| Keywords | ||
| Brucellosis; Comparative analysis; Epitopes Prediction; Molecular docking; Protein Modelling | ||
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