Effect of Garden Cress (Lepidium sativum) Extracts on Aflatoxin B1 and Blood Parameters in Rats | ||
| Journal of Agricultural Chemistry and Biotechnology | ||
| Article 2, Volume 9, Issue 10, October 2018, Pages 223-233 PDF (450.4 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jacb.2018.35392 | ||
| Authors | ||
| M. Sanad; S. Abou Talib; A. Yossef; M. Abbas | ||
| Dept. of Agric. Chemistry, Faculty of Agriculture, Mansoura University, Egypt. | ||
| Abstract | ||
| The crude chloroform and methanol extracts of Lepidium sativum seeds belong to family Brassicaceae,were used in this work to study their efficiency to reduce Aflatoxin B1 in rats. The more effective of chloroformic extract which decreased Aflatoxin B1 level from 8.7 to 1.0 ppb at a dose of 300 mg/kg body weight comparing with ligalon (Silymarin) which reduced Aflatoxin B1 to 0.97 ppb in concentration of 100 mg/kg after 5 weeks, followed by methanolic extract at a dose of 300 mg/kg body weight which showed the mean value of 1.2 ppb.Also, the more effective treatments may be Silymarin in concentration of 100 mg/kg followed by chloroformic extract, while methanolic extract of Lepidium sativum seeds was represented middle effect for blood tests of rats injured with Aflatoxin B1 e.g. Serum marker enzyme parameters (MDA, SOD, ALP and Bilirubin), kidney functions (Creatinine and Urea), liver functions (ALT, AST, Total proteins, Albumin and Globulins), lipid profile (triglycerides, total cholesterol, HDL-c, LDL-c and vLDL-c ) and haematological parameters (HB, RBCs, Plt and WBCs), were determined in injured rats comparing with control rats. It is quite clear that Silymarin is considered synthetic product, so the natural extracts of garden cress are more suitable for usage due to, they considered more safety and economic products, so these extracts can be additive to foodstuffs and therapeutic drugs owing to their multi medicinal benefits. | ||
| Keywords | ||
| Lepidium sativum seeds extracts; kidney functions; Liver functions; Silymarin and Aflatoxin B1 | ||
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