Changes in histopathological phenotypes of Schistosomaassociated urinary bladder cancer in Sohag, Egypt | ||
| Parasitologists United Journal | ||
| Article 4, Volume 17, Issue 1, April 2024, Pages 24-28 PDF (429.19 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/puj.2024.265820.1236 | ||
| Authors | ||
| Asmaa Abd Ellah* 1; Maisa Mohammed2 | ||
| 1Departments of Medical Parasitology, Faculty of Medicine, Sohag University, Sohag, Egypt | ||
| 2Departments of Pathology , Faculty of Medicine, Sohag University, Sohag, Egypt | ||
| Abstract | ||
| Background: Squamous cell carcinoma is the most common type in Egyptian bilharzial bladder. However, there is a proven changing pattern of Schistosoma-associated bladder cancer (SA-BC) that needs to be investigated. Objective: To assess the patterns (age, incidence, and histopathological types) of SA-BC in Sohag, Egypt. Material and Methods: This descriptive retrospective study included 152 patients histologically confirmed urinary BC diagnosed at the Pathology Department of Sohag University Hospital during 4 years, from January 2019 to December 2022. Data including age, sex, residence, and histopathological type were retrieved from the records of Pathology Department. Results: Patients’ age ranged from 35-79 years with a mean of 61.2±9.1 years, and male to female ratio was 4.6:1. Transitional cell carcinoma (TCC) was the most common histological type (80.9%), followed by squamous cell carcinoma (SCC) (12.5%), and TCC with squamous differentiation (6.6%). Schistosoma eggs were histologically confirmed in 39.5% of cancer cases; 76.7% were TCC, 21.7% were SCC and only 1.6% was TCC with squamous differentiation. All SA-BC were male with mean age of 59.8±7.5. At the time of diagnosis, 96.7% of SA-BC cases were bladder muscle invasive and 91.7% were of high-grade nature not significantly different from cases with non-Schistosome associated BC (NSA-BC). Conclusion: The histopathological patterns of SA-BC have changed in Egypt over the past decade and most cases were associated with TCC. | ||
| Keywords | ||
| bladder cancer; Sohag; Egypt; SCC; TCC; urinary schistosomiasis | ||
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