The Importance of Serum Fibroblast Growth Factor-23 in Obesity and Metabolic Syndrome, Potential Effect of Nutritional Therapy Intervention | ||
| Egyptian Journal of Chemistry | ||
| Volume 67, Issue 11, November 2024, Pages 363-376 PDF (919.43 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2024.266936.9269 | ||
| Authors | ||
| Salwa M. El Shebini1; Hend A. Essa* 1; Maha I. A. Moaty1; Nihad H. Ahmed1; Ahmed M. S. Hussein2; Magda S. Mohamed1 | ||
| 1Department of Nutrition and Food Science, National Research Center, 12622, Cairo, Egypt; | ||
| 2Department of Food Technology, National Research Centre, 12622, Cairo, Egypt | ||
| Abstract | ||
| Background: Fibroblast growth factor-23, a hormone, regulates circulating phosphate and vitamin D levels and also plays a role in some metabolic processes. Objective: A food supplement containing Moringa oleifera leaf flour and turmeric powder has been used in conjunction with a low-calorie diet to help people lose weight and improve metabolic and renal problems. Subjects and methods: Two-phase interventional study that lasted 8 weeks. Sixty-four volunteer women with varying degrees of obesity and metabolic syndrome criteria took part. Their mean age and BMI were 47.37± 1.31 years and 36.50±0.68 kg/m2, respectively. All participants followed a low caloric balanced diet for eight weeks. They ate moringa pies during the first phase and the regimen during the second. Patients were clinically, anthropometrically , dietary 24 h recall and biochemically monitored. Results: At the end of the first phase, there was a significant reduction in the mean values of the anthropometric and more in the biochemical parameters, which began to fade in the second phase. FGF-23 and various metabolic parameters were found to have negative significant correlations both at baseline and after intervention. Creatinine and IL1β showed a significant positive correlation but a significant negative correlation with eGFR. Conclusion: As a bakery product, the health effect of a dietary therapy supplemented with pies fortified with Moringa oleifera leaf and turmeric powder as anti-inflammatory and antidiabeic was demonstrated. The inverse relationship detected in this study between FGF-23 and metabolic syndrome parameters were suggested to maintained serum phosphorus hemostasis. Because of the link between FGF-23, creatinine, and eGFR, it could be used as a valuable factor in kidney function research. | ||
| Keywords | ||
| Metabolic syndrome; Obesity; Fibroblast growth factor-23; Moringa oleifera leaf; Turmeric | ||
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