Overview on synthetic strategies and bioactivities of pyrazolopyridines. | ||
| Egyptian Journal of Chemistry | ||
| Volume 67, Issue 12, December 2024, Pages 513-535 PDF (6.79 M) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/ejchem.2024.281932.9564 | ||
| Authors | ||
| samar Mogheith1; Heba Allam2; Manal Ezzat* 3; Samy Mohamady4 | ||
| 1Faculty of Pharmacy, BUE | ||
| 2Faculty of Pharmacy, Cairo University | ||
| 3Faculty of Pharmacy, Cairo University, Cairo, Egypt. | ||
| 4Pharmaceutical Chemistry Department, Faculty of Pharmacy, BUE | ||
| Abstract | ||
| There is undeniable evidence that many N-heterocycles exhibit a wide range of biological functions. Recently, derivatives with better bioactivities have been generated by condensing the different heterocycles. Pyrazolopyridines have been able to pique the interest of many researchers among many other condensed heterocycles, due to the wide range of actions they exhibit. Furthermore, each type of condensed heterocycle has been specifically highlighted in this review in terms of design and biological activities. In silico methods and structure-activity relationship have also been discussed wherever reported. | ||
| Keywords | ||
| Pyrazolopyridines; biological activities; SAR; Target; Kinase | ||
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