Evaluation Cyto-genotoxicity and nephrotoxicity caused by potassium bromate and the protective impact of sesame oil in male rats | ||
| Egyptian Journal of Histology | ||
| Articles in Press, Accepted Manuscript, Available Online from 13 May 2024 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejh.2024.279428.2047 | ||
| Author | ||
| Shaimaa Mohammed Ali jasim* | ||
| Biology ,faculty of sciences ,Kufa university | ||
| Abstract | ||
| Potassium bromate is commonly used in baking to add flavour and improve flour quality. It can also hurt many organs, especially the kidneys, by changing signs of kidney function. In this study, cytogenetic tests and histopathological examination of the kidney were used to identify the protective impact of sesame oil against the toxic influence of potassium bromate in bone marrow cells and kidney cortex tissue of male albino rats. Thirty-two male rats (Rattus norvegicus) were used, and the animals were divided into four groups; each group consisted of eight animals. The first group treated distilled water as a control, the second group treated sesame oil (4 ml /kg body weight), the third group received about (12 mg of potassium bromate per one kg body weight) and the fourth group treated with potassium bromate and sesame oil for 21 days. The results revealed a significant decrease of (p≤0.05) in the mitotic index in the potassium bromate group and the potassium bromate plus sesame oil group compared to the control group. The study recorded a significant increase (p≤0.05) in the chromosomal aberration rate in groups treated with potassium bromate compared to control groups administrated with distilled water and sesame oil after 21 days. Moreover, the current research identified histological changes in kidney cortex tissue in the group that administrated potassium bromate compared to the control. In addition, the results showed the positive role of sesame oil in significantly reducing potassium bromate toxicity in bone marrow cells and renal damage in the group animals treated by potassium bromate and sesame oil compared with the animal group treated by potassium bromate alone. Conclusion: sesame oil had protective role against the toxicity and adverse side effect of potassium bromate in bone marrow cells and kidney cortex tissue. | ||
| Keywords | ||
| Cyto-genotoxicity; Nephrotoxicity; Potassium bromate; Sesame oil | ||
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