Biochemical and Hematological Effects of Food Flavoring Furfural in Male Albino Rats | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 7, Volume 32, Issue 1, June 2012, Pages 93-110 PDF (275.02 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2012.35529 | ||
| Authors | ||
| Tarek Ali* 1; Osama Ahmed2; Rasha Ahmed3 | ||
| 1Physiology Department, Faculty of Medicine,Beni-Suef University. | ||
| 2Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University | ||
| 3Histology division, Zoology Department, Faculty of Science, Beni-Suef University | ||
| Abstract | ||
| Objectives: The present study aims to assess the effect of furfural, an aldehyde commonly used as food flavor in many foods, on the hematological and biochemical aspects in male albino rat. Materials and methods: The experimental animals used in the study were divided into four groups. The control group was given a daily volume of the vehicle dimethyl sulfoxide (DMSO) whereas the other three groups were orally administered furfural for 8 weeks in a dose of 3.18, 6.36 and 12.72 mg/kg body weight respectively. Blood samples were obtained for complete blood count (CBC), liver and kidney function tests. Serum α-fetoprotein (AFP) and carbohydrate antigen (CA19.9 were also measured. Results: Obtained results revealed a decrease in red blood corpuscles (RBCs) count, packed cell volume (PCV) and hemoglobin content and an increase in mean cell volume (MCV) and mean cell hemoglobin content (MCH) in rats received furfural in a dose dependent manner. The white blood cells (WBC) count was decreased specially esinophils percentage was depleted in the low and medium doses groups. Furfural elevated serum liver enzymes activities and total bilirubin concentration. The serum total proteins and albumin levels were increased in medium and high doses groups, while globulin level, was elevated only in low dose group. Furfural elevated serum urea level but did not affect serum AFP and CA19.9 levels in all groups. Conclusions: In conclusion, furfural administration to rats induces a sort of macrocytic anemia, leucopenia, esinopenia and elevated liver enzymes and urea in rats in a dose related manner. | ||
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