EVALUATION OF THE POTENTIAL EFFECT OF CURCUMIN AND/OR PARACETAMOL IN PREGNANT WISTAR RATS AND THEIR FETUSES | ||
| Egyptian Journal of Zoology | ||
| Articles in Press, Accepted Manuscript, Available Online from 27 May 2024 PDF (1.37 M) | ||
| Document Type: Original Research Papers | ||
| DOI: 10.21608/ejz.2024.274415.1113 | ||
| Authors | ||
| Heba Ali Abd El Rahman* ; Dina M. Ali; Amel R. Omar | ||
| Zoology Department, Faculty of Science, Cairo University, Giza, Egypt | ||
| Abstract | ||
| The present study aimed to assess the potential effects of curcumin and/or paracetamol on maternal Wistar rats (Rattus norvegicus)and their fetuses during gestation. The pregnant female Wistar rats were allotted into four groups (6 rats/each group): the control group received daily/orally vehicle, curcumin (15.75 mg/kg body weight) group, paracetamol (350 mg/kg body weight) group, and the combined group received paracetamol and curcumin simultaneously during gestation (6th–19th days). This study measured pregnancy outcome parameters, fetal skeletal status, hepatic oxidative stress, and histological changes. The current results revealed the unsafe consequence of paracetamol on the pregnancy outcome. At the same time, it induced fetal growth retardation, hepatic histological alterations, and altered significantly (P<0.05) the maternal and fetal hepatic oxidative status. Paracetamol intake did not affect skeletal bone ossification. On the contrary, curcumin daily intake alleviated the negative impact of paracetamol and improved fetal growth parameters, restored the normal hepatic histology, decreased lipid peroxidation levels, and increased antioxidants in maternal and fetal liver tissues. In conclusion, curcumin could be approved as a protective agent that reverses the toxic effect of paracetamol during gestation. Further studies will be done to illustrate the precise mechanisms and pathways by which the curcumin can alleviate the paracetamol impact. | ||
| Keywords | ||
| Curcumin; Gestation; Oxidative stress; Paracetamol; Rats’ fetuses | ||
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