Effects of Copper (II) Albumin Complex on Thermal Skin Burn | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 3, Volume 32, Issue 2, December 2012, Pages 31-42 PDF (542.31 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2012.35796 | ||
| Authors | ||
| Amany Mohamed* 1; Ahmed Nassar1; Manal Mandour1; Heba Saad Eldien2; Ghada Mohammed3 | ||
| 1Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt | ||
| 2Department Histology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||
| 3Department of Medical Biochemistry , Faculty of Medicine, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| Background: Thermal burn results in release of many chemical mediators such as free radicals, biogenic amines and neurotransmitters. The modulations of these mediators can enhance burn wound healing. Aim of the Work: To evaluate effects of copper (II) albumin complex on thermal wound healing. Materials and Methods: An animal model of 190 Sprague Dawely rats was established. Ten rats served as a control group and 180 rats were exposed to 10% total body surface area full thickness thermal burn. The rats were equally divided into three groups and treated topically either with soft paraffin, moist exposed burn ointment (MEBO), or with copper (II) albumin complex. At 4 hours, first day, third day, first week, second week and third week post-injury, plasma was used for determination of malondialdehyde (MDA), total antioxidant capacity (TAC), 5- hydroxy tryptamine (5-HT) and gamma amino butyric acid (GABA). Skin tissues were taken for histopathological examination with light microscopy. Results: Thermal injury resulted in a significant increase of plasma levels of MDA, 5- HT and GABA and a significant decrease of TAC. The treated groups with copper (II) albumin complex and MEBO showed a significant decrease of plasma levels of MDA and 5-HT and a significant increase of plasma levels of TAC. Copper (II) albumin complex treatment was associated with a significant increase of plasma levels of GABA at the first and third day post-burn as compared to the other treated groups. Characteristic enhancement of regeneration of epidermis and hair follicles was observed following application of copper (II) albumin complex. Conclusions: The topical application of copper (II) albumin complex was associated with improved healing signs of full thickness thermal burn due to its antioxidant, antiinflammatory and pain modulating effects. | ||
| Keywords | ||
| thermal burn; copper (II) albumin complex; MEBO | ||
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