Novel Schiff Base Metal Complexes and Their Biological Applications | ||
| Egyptian Journal of Chemistry | ||
| Volume 68, Issue 1, January 2025, Pages 571-578 PDF (1.18 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2024.227486.8375 | ||
| Authors | ||
| Walaa H Mahmoud1; moustafa M goha2; Taha Eldebss3; Ahmed Abdo El-Sherif* 1 | ||
| 1Faculty of science, Cairo university | ||
| 2chemistry, faculty of science, Cairo university | ||
| 3organic chemistry department, faculty of science , cairo university | ||
| Abstract | ||
| Cr(III), Zn(II), Ni(II) and Cu(II) complexes of a symmetric Schiff base ligand (L), (Z)-N'-((1E,2E)-1-(2-(p-tolyl)hydrazineylidene)propan-2-ylidene)-2-((E)-1-(2-(p-tolyl)hydrazineylidene)propan-2-ylidene)hydrazine-1-carbohydrazide has been synthesized. Elemental analysis, UV-Visible, FT-IR, mass spectra and conductometric techniques were used to characterise the ligand and its metal complexes. The microorganisms utilized in this study involve Streptococcus mutans, Staphylococcus Aureus (as Gram-positive bacteria), Escherichia Col and Klebsiella pneumonia (as Gram-negative bacteria) and Aspergillus Nigar and Candida albicans (as fungi). Comparing all of the studied species, Cu(II) complex exhibits the highest activity versus tested fungi. | ||
| Keywords | ||
| Schiff base; complexes; spectra: Molecular docking; Antimicrobial activity | ||
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