Oxidative Stress in Classic Type Lichen Planus | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 10, Volume 32, Issue 2, December 2012, Pages 125-134 PDF (186.96 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2012.35846 | ||
| Authors | ||
| Mohammed Abdel-Karim* 1; Nagwa Ahmed2; Asmaa Abdel-Mawgoud3 | ||
| 1Dermatology, Venerology and Andrology Department, Faculty of Medicine, Sohag University | ||
| 2Biochemistry Department, Faculty of Medicine, Sohag University | ||
| 3Dermatology, Venerology and Andrology Department, Faculty of Medicine, Sohag University | ||
| Abstract | ||
| Background: Lichen planus (LP) is an autoimmune inflammatory disease of the mucocutaneous tissue, whose exact pathological course is not yet understood. Many studies have implicated the role of reactive oxygen species (ROS) and the protective role of antioxidants in several autoimmune skin disorders. Aim of study: is to evaluate the role of oxidant/antioxidant status in patients with classic type lichen planus. Patients and Methods: The study included 30 patients of classic type lichen planus attending Dermatology, Venereology and Andrology Outpatient Clinic in Sohag University Hospital, and 20 healthy controls. Serum and tissue levels of nitric oxide(NO),malondialdehyde (MDA), superoxide dismutase(SOD), and catalase (CAT) were measured in patients with classic type lichen planus. Results: The LP patients showed statistically significant higher level of serum and tissue NO, MDA and SOD compared to that of controls. On the other hand, patients showed statistically significant lower level of serum and tissue CAT. Male patients showed statistically significant higher levels of serum NO, MDA and SOD than that of female patients. On the other hand, male patients had statistically significant lower level of serum and tissue CAT when compared with female patients. On the other hand male patients showed statistically significant lower levels of serum and tissue CAT than that of male controls. Conclusions: The imbalance between oxidant/ antioxidant mechanisms may be a primary etiological factor or a secondary possible etiological factor in pathogenesis of classic LP. | ||
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