Inflammation versus Oxidative Stress in Pathophysiology of Cognitive Dysfunction induced by Aluminum Chloride in Male Rats | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 15, Volume 32, Issue 2, December 2012, Pages 201-222 PDF (951.91 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2012.35861 | ||
| Author | ||
| Omyma Ahmed* | ||
| Department of Physiology, Faculty of Medicine, Assiut University, Assiut, EGYPT | ||
| Abstract | ||
| Alzheimer's disease (AD) is a highly debilitating neurodegenerative disorder characterized by cognitive dysfunction, inflammation and oxidative stress are thought to play major roles in pathophysiology of the AD, which of them have a principle role is unclear. The role of brain growth factors, cytokines and oxidative biomarkers in cognitive dysfunction induced by AlCL3 in rats with application of anti-inflammatory (cilostazol) and antioxidant (N-acetyl cysteine, NAC) were investigated to clarify the predominant pathophysiological mechanism involved. Methods: Alzheimer's model group was given AlCL3 (100 mg/kg-) orally for 6 weeks. Alzheimer's model + NAC and Alzheimer's model + cilostazol groups were given (NAC) and cilostazol respectively one hr. before AlCL3 for the same duration. Results: anti-inflammatory or antioxidant significantly improved memory retention which was evaluated by Morris Water Maze, passive avoidance task and eight-arm radial maze. This improvement was consistent with histological recovery and was mediated by reduction AlCL3 concentration in the brain hippocampus and frontal cortex, interference with the cholinergic dysfunction as well as prevention of oxidative damage. In addition, anti-inflammatory agent can modulate superiorly the inflammatory response via reduction the levels of inflammatory cytokines and adjustment the levels of brain–derived neurotrophic factors and transforming growth factor B. This finding supports the principal role of inflammation in pathophysiology of AD and suggests the potential therapeutic application of anti-inflammatory agent for this condition. | ||
| Keywords | ||
| Brain –derived neurotrophic factors (BDNF); transforming growth factor-B (TGF-B); cognitive function test; AlCl3; Cilostazol; Nacetyl cysteine; inflammatory cytokines and oxidative biomarkers | ||
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