Plasma level of MiR- 200b in type 2 diabetic retinopathy in Egyptian patients | ||
| Benha Medical Journal | ||
| Article 18, Volume 41, Issue 8, December 2024, Pages 585-595 PDF (886.73 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2024.289866.2081 | ||
| Authors | ||
| Ibrahim Mohamed Rageh1; Enas Sebaey Ahmad2; Mohamed Nagy El-Mohamady3; Mirna Mashhour4; Rehab Adel Zeiada* 5; Dina Saad Abdelmotaleb6 | ||
| 1Professor of Clinical and Chemical Pathology - Immunology Faculty of Medicine - Benha University | ||
| 2Assistant professor of Clinical and Chemical pathology Faculty of Medicine - Benha University | ||
| 3Assistant professor of Ophthalmology Faculty of Medicine - Benha University | ||
| 4Internal Medicine Fellowship Trainee Benha Health Insurance Hospital | ||
| 5department of of Clinical and Chemical pathology Faculty of Medicine - Benha University | ||
| 6Lecturer of Clinical and Chemical Pathology, Faculty of Medicine, Benha University | ||
| Abstract | ||
| Background: The incidence of diabetes mellitus is rapidly increasing, and it frequently causes considerable metabolic disorders and serious consequences. MicroRNA-200b (miR-200b) is a regulator of angiogenesis that has emerged as a diagnostic and predictive tool for certain disorders. Aim: to investigate the association of miR-200b with diabetic retinopathy (DR). Methods: The study included 100 subjects from Benha University Hospital: 40 patients with type 2 diabetes (T2D) without DR, 40 with T2D and DR, and 20 healthy controls. MicroRNA-200b was assessed for all subjects using real time PCR with SYBR Green. Results: Diabetics had lower levels of miR-200b than healthy controls. While, those without DR had even lower miR-200b levels compared to those who did have DR. Additionally, lower miR-200b levels were associated with neuropathy but not with nephropathy. Conclusion: MiR-200b showed promise as a biomarker for both T2D and DR. It perfectly differentiated diabetic patients with and without retinopathy, while offering moderate accuracy for diagnosing diabetes in general. These findings suggest miR-200b may play a risky role in DR among diabetics, and further research is warranted to confirm these results. | ||
| Keywords | ||
| T2D; diabetic retinopathy; miR-200b; micro-RNA | ||
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