The Effect of Oral Contraceptive: Different Patterns of Use on Circulating IGF-1 and Bone Mineral Density in Healthy Premenopausal Women. | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 20, Volume 32, Issue 2, December 2012, Pages 279-292 PDF (186.34 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2012.35926 | ||
| Authors | ||
| Amany Elkazaz* 1; Khaled Salama2 | ||
| 1Department of Medical Biochemistry, Faculty of Medicine, Suez Canal University | ||
| 2Department of Orthopedic Surgery, Faculty of Medicine, Suez Canal University | ||
| Abstract | ||
| Background: Both insulin like growth factor-1(IGF-1) and oral contraceptive (OC) use have been linked to premenopausal breast and colorectal cancers, osteoporosis and cardiovascular disease. Understanding the effects of different patterns of use of OC on IGF-1 levels and bone mineral density (BMD) may offer insight into its influence on osteoporosis. Methods: We conducted a cross-sectional study of 135 women who were included into 3 groups (Group A= OC users, 43 women; Group B who never use OC, 51 women; and Group C who were past users, 41 women). Each patient completed a questionnaire on demographic parameters, marital state history, and contraception history including duration of use and type of contraceptive pills or used method. Lower end radius, proximal femur and lumbar spine BMD were measured by dual-energy X-ray absorptiometry. IGF-1 was assessed with chemiluminescent immunometric assay. Results: The 3 groups were matched for age and BMI, and nearly similar in total body T- value of BMD (with slight better results in past-users than the other 2 groups but it was statistically insignificant difference), but the other BMD values shows significant difference between the studied groups regarding the measurement at lumbar spine and femur which were statistically significantly better results in Group C (past users). Among past-users women the mean level of circulating IGF-1 was higher than the other 2 groups, and that difference was statistically significant. Conclusion: Lower IGF-1 level among current users may also potentially lead to decreased BMD, while the higher levels we observed in older past users may decrease the osteoporosis risk, reflecting observed relationship between IGF-1, BMD, and oral contraceptives. | ||
| Keywords | ||
| IGF-1; BMD and Oral contraceptives | ||
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