Light and electron microscopic study of the effect of paracetamol on the heart of adult male albino rats and the possible protective effect of vitamin C | ||
| Kasr Al Ainy Medical Journal | ||
| Volume 26, Issue 1, September 2020 PDF (3.07 M) | ||
| DOI: 10.4103/kamj.kamj_9_20 | ||
| Author | ||
| Rasha A. Gaber | ||
| Abstract | ||
| Paracetamol is used to treat several conditions like headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. There are several side effects which result from administration of paracetamol, as it may affect liver, kidney and even heart. Unexplained deaths and electrocardiographic changes associated with paracetamol poisoning have also been reported and wasn’t been clearly discussed. Material and methods: The experimental study was carried out on 15 rats. The animals were divided into 3 groups, each group consists of 5 rats: Group1: Healthy control rats. Group 2: Rats received (0.5) ml of paracetamol/kg BW (oral).Group 3: Rats received (0.5) ml of paracetamol/kg BW (oral), and vitamin C (200 mg/kg BW). The animals were anesthetized by ether, the chest was opened to expose the heart for intracardiac perfusion with 10 ml of isotonic solution until the coming fluid is clear of blood, then 10% neutral buffered formalin. Each group is divided into two subgroups. The first subgroup was processed for light microscopy, and the second subgroup was processed for electron microscopy Treatment was done once daily for continuous 30 days. Results were in the form of presence of muscle disruption, invasion of muscle fibers by inflammatory cells, severely dilated and congested blood vessels, numerous and giant mitochondria. But, in group III there was some amelioration in the form of decrease in disruption of muscle fibers, decrease in congestion of blood vessels and mitochondria appeared in a normally arranged manner. The statistical analysis showed hypertrophy of muscle fibers in group II, and slight resolution in the hypertrophy in group III. | ||
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